Browsing Department of Chemical and Biological Engineering by Author "4f214a1d-3ffa-4a38-bb8f-9905a0bb760d"
Now showing items 1-7 of 7
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DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
Husseini, Ghaleb; El-Fayoumi, Refaat I.; O'Neill, Kim L.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2000)To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ... -
Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
Marin, Alexander; Sun, Hao; Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2002)The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant ... -
Factors affecting acoustically triggered release of drugs from polymeric micelles
Husseini, Ghaleb; Myrup, Gregg D.; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2000)A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ... -
Intracellular uptake of Pluronic copolymer: effects of the aggregation state
Muniruzzaman, Md.; Marin, Alexander; Luo, Yi; Prestwich, Glenn D.; Pitt, William G.; Husseini, Ghaleb; Rapoport, Natalya Y. (Elsevier, 2002)The effect of the Pluronic P-105 aggregation state on its uptake by HL-60 cells was studied by flow cytometry, fluorescence spectroscopy, and confocal and fluorescence microscopy using a fluorescently labeled Pluronic P105. ... -
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
Husseini, Ghaleb; Rapoport, Natalya Y.; Christensen, Douglas A.; Pruitt, John D.; Pitt, William G. (Elsevier, 2001)The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ... -
Stabilization of Pluronic P-105 Micelles with an Interpenetrating Network of N,N-Diethylacrylamide
Pruitt, John D.; Husseini, Ghaleb; Rapoport, Natalya Y.; Pitt, William G. (American Chemical Society, 2000)N,N-Diethylacrylamide (NNDEA) was polymerized in the presence of Pluronic P-105 micelles. The polymerizations resulted in an interpenetrating network of poly(NNDEA) and P-105 that stabilized the micelles at concentrations ... -
Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide
Husseini, Ghaleb; Christensen, Douglas A.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2002)Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...