Browsing Department of Chemical and Biological Engineering by Author "7445120e-99f1-4dee-9867-c0760473e308"
Now showing items 1-7 of 7
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Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound
Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Dickinson, David J. (Elsevier, 2009)The majority of research in the area of acoustically-activated drug delivery from stabilized micelles has been focused on the rapid release of chemotherapy drugs from the core of such nano-carriers. Previous publications ... -
Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
Marin, Alexander; Sun, Hao; Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2002)The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant ... -
Factors affecting acoustically triggered release of drugs from polymeric micelles
Husseini, Ghaleb; Myrup, Gregg D.; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2000)A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ... -
Investigating the acoustic release of doxorubicin from targeted micelles
Husseini, Ghaleb; Velluto, Diana; Kherbeck, Laura; Pitt, William G.; Hubbell, Jeffrey A.; Christensen, Douglas A. (Elsevier, 2013)The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable ... -
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
Husseini, Ghaleb; Rapoport, Natalya Y.; Christensen, Douglas A.; Pruitt, John D.; Pitt, William G. (Elsevier, 2001)The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ... -
Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound
Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Gabuji, Tasneem; Zeng, Yi; Christensen, Douglas A.; Pitt, William G. (American Scientific Publishers, 2007)Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ... -
Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide
Husseini, Ghaleb; Christensen, Douglas A.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2002)Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...