Browsing Department of Chemical and Biological Engineering by Title

Now showing items 159-178 of 191

    • Systems and Methods for Targeted Breast Cancer Therapies 

      Husseini, Ghaleb; Al-Sayah, Mohammad; Ahmed, Amal Elsadig Elamir (2020-12-15)
      Systems and methods for producing liposomes , including control liposomes and immunoliposomes targeting breast cancer are provided . Systems and methods for treating breast cancer , using targeted immunoliposomes produced ...

    • Systems and Methods for Targeted Breast Cancer Therapies 

      Husseini, Ghaleb; Al-Sayah, Mohammad; Ahmed, Amal Elsadig Elamir (2024-01-09)
      Systems and methods for producing liposomes, including control liposomes and immunoliposomes targeting breast cancer are provided. Systems and methods for treating breast cancer, using targeted immunoliposomes produced ...

    • Targeting Breast Cancer Using Hyaluronic Acid-Conjugated Liposomes Triggered with Ultrasound 

      Ben-Daya, Mohamed; Paul, Vinod; Awad, Nahid S.; AlSawaftah, Nour Majdi; Al-Sayah, Mohammad; Husseini, Ghaleb (American Science Publishers, 2021)
      The successful targeting of tumors can be achieved by conjugating targeting moieties to nanoparticles. These modifications allow nannocarriers to achieve greater targeting specificity through binding to specific receptors ...

    • Targeting the Folate Receptor: Effects of Conjugating Folic Acid to DOX Loaded Polymeric Micelles 

      Elkhodiry, Mohamed A.; Husseini, Ghaleb; Velluto, Diana (Bentham Science Publishers, 2016)
      In this paper, we report on a potential cancer drug delivery system that utilizes the ligand targeting of the folate receptor. Our drug delivery system consists of Pluronic-P105 micelles, targeted with folic acid moieties. ...

    • Technique for Drug and Gene Delivery to the Cell Cytosol 

      Pitt, William G.; Husseini, Ghaleb (2015-04-07)
      Provided herein is a composition, a method, and a system for delivering a functional molecule to the cytosol of a cell, comprising a liposome configured to be taken into a cell, including by a process selected from the ...

    • Thermal Conductivities of Choline Chloride-Based Deep Eutectic Solvents and Their Mixtures with Water: Measurement and Estimation 

      Ibrahim, Taleb; Sabri, Muhammad Ashraf; Abdel-Jabbar, Nabil; Nancarrow, Paul; Mjalli, Farouq Sabri; AlNashef, Inas (MDPI, 2020)
      The thermal conductivities of selected deep eutectic solvents (DESs) were determined using the modified transient plane source (MTPS) method over the temperature range from 295 K to 363 K at atmospheric pressure. The results ...

    • Thermal Conductivities of Choline Chloride-Based Deep Eutectic Solvents and Their Mixtures with Water: Measurement and Estimation 

      Ibrahim, Taleb; Sabri, Muhammad Ashraf; Jabbar, Nabil Abdel; Nancarrow, Paul; Mjalli, Farouq Sabri; AlNashef, Inas (MDPI, 2020)
      The thermal conductivities of selected deep eutectic solvents (DESs) were determined using the modified transient plane source (MTPS) method over the temperature range from 295 K to 363 K at atmospheric pressure. The results ...

    • Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems 

      Abuwatfa, Waad Hussein; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)
      Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven ...

    • Toxicological impact of nanoparticles on human health: A review 

      Mohamed, Omnia A.; Ajith, Saniha Aysha; Sabouni, Rana; Husseini, Ghaleb; Karami, Abdollah; Bai, Renu Geetha (American Scientific Publishers, 2022)
      Nanotechnology is a rapidly growing industry where nanomaterials are used in almost every field, including electronics, cosmetics, engineering, household products, biotechnology and medicine. Nanoparticles (NPs) have unique ...

    • Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review 

      Kawak, Paul S.; AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (MDPI, 2026-08-26)
      Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective ...

    • Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells 

      AlSawaftah, Nour Majdi; Awad, Nahid S.; Paul, Vinod; Kawak, Paul S.; Al-Sayah, Mohammad; Husseini, Ghaleb (Nature, 2021)
      Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency ...

    • Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment 

      Awad, Nahid S.; Salkho, Najla; Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Elsevier, 2023)
      Delivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. ...

    • Ultrasonic Drug Delivery Using Micelles and Liposomes 

      Martins, Ana M.; Ahmed, Salma E.; Vitor, Rute F.; Husseini, Ghaleb (Springer, 2016)
      The encapsulation of drugs in nanocarriers revolutionized research in drug delivery, especially in cancer chemotherapeutics. Several nanosystems have been developed including liposomes, polymeric micelles, dendrimers, solid ...

    • Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide 

      Husseini, Ghaleb; Christensen, Douglas A.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2002)
      Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...

    • Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment 

      Husseini, Ghaleb; Pitt, William G. (Wiley InterSciences, 2008)
      The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective ...

    • Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy 

      Awad, Nahid S.; Paul, Vinod; Al-Sayah, Mohammad; Husseini, Ghaleb (Taylor and Francis Online, 2019)
      Targeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumor site. Once at the tumor site, it is important that these liposomes are triggered to release ...

    • Ultrasonically triggered drug delivery: Breaking the barrier 

      Husseini, Ghaleb; Pitt, William G.; Martins, Ana M. (Elsevier, 2014)
      The adverse side-effects of chemotherapy can be minimized by delivering the therapeutics in time and space to only the desired target site. Ultrasound offers one fairly non-invasive method of accomplishing such precise ...

    • Ultrasound in drug and gene delivery 

      Pitt, William G.; Husseini, Ghaleb (Elsevier, 2008)
      In this issue, we present the current applications and future prospects of ultrasound in various aspects of drug and gene delivery. There are many advantages to ultrasound that make it ideal for the delivery of therapeutics ...

    • Ultrasound Triggering of Liposomal Nanodrugs for Cancer Therapy: A Review 

      Bahutair, Wafa N.; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2022)
      Efficient conventional chemotherapy is limited by its nonspecific nature, which causes severe systemic toxicity that can lead to patient discomfort and low therapeutic efficacy. The emergence of smart drug delivery systems ...

    • Ultrasound-Induced Calcein Release From eLiposomes 

      Lattin, James R.; Pitt, William G.; Belnap, David M.; Husseini, Ghaleb (Elsevier, 2012)
      Ultrasound is explored as a method of inducing the release of encapsulated materials from eLiposomes, defined as liposomes containing emulsion droplets. Emulsions were formed using perfluorohexane and perfluoropentane. ...