Now showing items 76-95 of 191
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In Vitro Evaluation of Ultrasound Effectiveness in Controlling Doxorubicin Release from Albumin-Conjugated Liposomes
(American Scientific Publishers, 2022)Functionalized liposomes are among the most promising antineoplastic agents delivery vehicles. Contemporaneous to their accretion at the tumor site, they need to be potentiated to release their cargo using a suitable ... -
Incorporating Computer-Aided Software in the Undergraduate Chemical Engineering Core Courses
(Chemical Engineering Education, 2014)Introductions of computer-aided software and simulators are implemented during the sophomore-year of the chemical engineering (ChE) curriculum at the American University of Sharjah (AUS). Our faculty concurs that software ... -
Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy
(Elsevier, 2023)The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the ... -
Intracellular uptake of Pluronic copolymer: effects of the aggregation state
(Elsevier, 2002)The effect of the Pluronic P-105 aggregation state on its uptake by HL-60 cells was studied by flow cytometry, fluorescence spectroscopy, and confocal and fluorescence microscopy using a fluorescently labeled Pluronic P105. ... -
Investigating the acoustic release of doxorubicin from targeted micelles
(Elsevier, 2013)The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable ... -
Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers
(American Scientific Publishers, 2015)Folic acid (FA) is one of the most utilized moieties in active (ligand) drug delivery. The folate receptor is widely expressed on the surface of several cell lines and tumors; including ovarian, brain, kidney, breast, and ... -
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
(BioMed Central (BMC), 2002)Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and ... -
Investigating the Release Mechanism of Calcein from eLiposomes at Higher Temperatures
(American Scientific Publishers, 2014)Numerous nanocarriers are currently being investigated as drug delivery vehicles for transporting chemotherapeutics to cancer cells. Our research group has recently synthesized a new generation of echogenic liposomes based ... -
Investigating the Stability of eLiposomes at Elevated Temperatures
(Sage Publishing, 2014)eLiposomes encapsulate a perfluorocarbon nanoemulsion droplet inside a liposome. Ultrasound is then used as a trigger mechanism to vaporize the perfluorocarbon, break the liposome, and release the desired drug to the tumor ... -
Ionic liquids and deep eutectic solvents for the recovery of phenolic compounds: effect of ionic liquids structure and process parameters
(Royal Society of Chemistry, 2021)Water pollution is a severe and challenging issue threatening the sustainable development of human civilization. Besides other pollutants, waste fluid streams contain phenolic compounds. These have an adverse effect on the ... -
Kinetics and thermodynamics of acoustic release of doxorubicin from non-stabilized polymeric micelles
(Elsevier, 2010)This paper studies the thermodynamic characteristics of ultrasound-activated release of Doxorubicin (Dox) from micelles. The release and re-encapsulation of Dox into Pluronic® P105 micelles was measured by recording the ... -
Kinetics of acoustic release of doxorubicin from stabilized and unstabilized micelles and the effect of temperature
(Elsevier, 2011)Ultrasound is being investigated as a trigger mechanism to deliver high concentrations of chemotherapy drugs to cancerous tissues using polymeric micelles. In this paper, we examined the kinetics of acoustic release of ... -
The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound
(American Scientific Publishers, 2022)Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable ... -
Kinetics of Ultrasonic Drug Delivery from Targeted Micelles
(American Scientific Publishers, 2015)To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This ... -
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
(Elsevier, 2001)The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ... -
Lessons learned from the underrepresentation of women in STEM: AI-enabled solutions and more
(Elsevier, 2021)The absence of women in STEM and energy sectors is driven by discrimination and socio-cultural factors. A greater number of women “leak out” from Energy and STEM fields than men. AI-enabled solutions offer analysis tools ... -
Liposomal Encapsulation of Chemotherapeutics Agents Combined with the Use of Ultrasound in Cancer Treatment
(American Scientific Publishers, 2023-07)Ultrasound (US) has numerous uses in the medical field, including imaging, tumor ablation, and lithotripsy; another interesting application of US in cancer therapy is as an external trigger in targeted drug delivery. ... -
Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment
(Bentham Science, 2017)The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a ... -
Liposomes for the Treatment of Brain Cancer — A Review
(MDPI, 2023-06-25)Due to their biocompatibility, non-toxicity, and surface-conjugation capabilities, liposomes are effective nanocarriers that can encapsulate chemotherapeutic drugs and facilitate targeted delivery across the blood–brain ... -
Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery
(Bentham Science Publishers, 2019)Cancer has become one of the most deadly noncommunicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy with low side effects. The most common ...
