Browsing Department of Chemical and Biological Engineering by Author "52d629dc-7d2f-47b9-aa2d-258b92e45ae1"
Now showing items 21-40 of 127
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Comprehensive Study of a Diabetes Mellitus Mathematical Model Using Numerical Methods with Stability and Parametric Analysis
AlShurbaji, Mohammad; Kader, Lamis Abdul; Hannan, Hadia; Mortula, Maruf; Husseini, Ghaleb (MDPI, 2023-01-04)Diabetes is sweeping the world as a silent epidemic, posing a growing threat to public health. Modeling diabetes is an effective method to monitor the increasing prevalence of diabetes and develop cost-effective strategies ... -
Cytosolic Delivery of Doxorubicin from Liposomes to Multidrug-Resistant Cancer Cells via Vaporization of Perfluorocarbon Droplets
Williams, Jacob B; Buchanan, Clara M.; Husseini, Ghaleb; Pitt, William G. (MedCrave, 2017)A common mechanism of multidrug resistance is the upregulation of efflux pumps in the cancer cells that can more rapidly export unwanted materials (e.g. cancer drugs) out of the cell, compared to sensitive cancer cells. ... -
Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound
Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Dickinson, David J. (Elsevier, 2009)The majority of research in the area of acoustically-activated drug delivery from stabilized micelles has been focused on the rapid release of chemotherapy drugs from the core of such nano-carriers. Previous publications ... -
Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery
Staples, Bryant J.; Pitt, William G.; Roeder, Beverly L.; Husseini, Ghaleb; Rajeev, Deepthi; Schaalje, G. Bruce (Elsevier, 2010)Ultrasound (US) increases efficacy of drugs delivered from micelles, but the pharmacokinetics have not been studied previously. In this study, US was used to deliver doxorubicin (Dox) sequestered in micelles in an in vivo ... -
DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
Husseini, Ghaleb; El-Fayoumi, Refaat I.; O'Neill, Kim L.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2000)To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ... -
Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
Marin, Alexander; Sun, Hao; Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2002)The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant ... -
Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review
Tanbour, Rafeeq Kamal; Martins, Ana M.; Pitt, William G.; Husseini, Ghaleb (Bentham Science Publishers, 2016)Anti-neoplastic drugs used for cancer treatment often produce damage to healthy cells, leading to severe side effects in patients undergoing chemotherapy. The encapsulation of these agents in nanoparticles reduces the ... -
Dual-Targeting and Stimuli-Triggered Liposomal Drug Delivery in Cancer Treatment
AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (American Chemical Society, 2021)The delivery of chemotherapeutics to solid tumors using smart drug delivery systems (SDDSs) takes advantage of the unique physiology of tumors (i.e., disordered structure, leaky vasculature, abnormal extracellular matrix ... -
Effect of High-Frequency Ultrasound on Targeted Liposomes
AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (American Scientific Publishers, 2022)Delivering highly toxic drugs inside a safe carrier to tumors while achieving a controlled and effective drug release at the targeted sites represents an attractive approach to enhance drug efficiency while reducing its ... -
Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes
Ahmed, Salma E.; Moussa, Hesham Gamal; Martins, Ana M.; Al-Sayah, Mohammad; Husseini, Ghaleb (De Gruyter, 2016)The use of liposomes as carriers for chemotherapeutic agents in combination with ultrasound as a stimulus to control the time and space of the drug release is a promising approach for cancer treatment, as it can reduce the ... -
Effect of phospholipid head group on ultrasound‑triggered drug release and cellular uptake of immunoliposomes
Awad, Nahid S.; Paul, Vinod; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Nature, 2023)Liposomes are the most successful nanoparticles used to date to load and deliver chemotherapeutic agents to cancer cells. They are nano-sized vesicles made up of phospholipids, and targeting moieties can be added to their ... -
An Effective Anticancer Nano-approach for Melanoma and Breast Cancers Using Annona muricate Gold Nanoparticles
Imran, Muhammad; Husseini, Ghaleb; Awad, Nahid S.; Paul, Vinod; El-Haj, Babiker M.; Ali, Heyam Saad (Acta Scientific, 2021-09)Chemotherapy is preferred for the treatment and management of cancer; however, its efficacy is hindered by the off-target side effects of the currently used synthetic drugs. Thus, anticancer drugs with higher safety and ... -
Encapsulation and release of calcein from herceptin-conjugated eLiposomes
Zafar, Mah Noor; Pitt, William G.; Husseini, Ghaleb (Elsevier, 2024-03)Achieving an optimal therapeutic level is crucial in effectively eradicating cancer cells during treatment. However, conventional chemotherapy-associated systemic administration of anticancer agents leads to many side ... -
Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review
Ibrahim, Mihad; Abuwatfa, Waad Hussein; Awad, Nahid S.; Sabouni, Rana; Husseini, Ghaleb (MDPI, 2022)Doxorubicin (DOX) is one of the most widely used anthracycline anticancer drugs due to its high efficacy and evident antitumoral activity on several cancer types. However, its effective utilization is hindered by the adverse ... -
Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging
Farooq, Afifa; Sabah, Shafiya; Dhou, Salam; AlSawaftah, Nour Majdi; Husseini, Ghaleb (MDPI, 2022)The field of cancer theranostics has grown rapidly in the past decade and innovative ‘biosmart’ theranostic materials are being synthesized and studied to combat the fast growth of cancer metastases. While current ... -
Factors affecting acoustically triggered release of drugs from polymeric micelles
Husseini, Ghaleb; Myrup, Gregg D.; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2000)A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ... -
Factors affecting sedimentational separation of bacteria from blood
Pitt, William G.; Alizadeh, Mahsa; Blanco, Rae; Hunter, Alex K.; Bledsoe, Colin G.; McClellan, Daniel S.; Wood, Madison E.; Wood, Ryan L.; Ravsten, Tanner V.; Hickey, Caroline L.; Beard, William Cameron; Stepan, Jacob R.; Carter, Alexandra; Husseini, Ghaleb; Robison, Richard A.; Welling, Evelyn; Torgesen, Rebekah N.; Anderson, Clifton M. (American Institute of Chemical Engineers (AIChE), 2019)Rapid diagnosis of blood infections requires fast and efficient separation of bacteria from blood. We have developed spinning hollow disks that separate bacteria from blood cells via the differences in sedimentation ... -
Factors Affecting the Acoustic In Vitro Release of Calcein from PEGylated Liposomes
Ahmed, Salma E.; Moussa, Hesham Gamal; Martins, Ana M.; Abbas, Yassmine; Al-Sayah, Mohammad; Husseini, Ghaleb (American Scientific Publishers, 2019)Typical methods used in cancer treatment, including chemotherapy, are debilitating because of the various adverse side effects experienced by cancer patients. The free drug injected into the patient at given doses affects ... -
Folic Acid Quenches Doxorubicin Fluorescence Letter to the Editor
Husseini, Ghaleb (American Scientific Publishers, 2012) -
Gas Phase Deposition of Trichloro(1H,1H,2H,2H-perfluorooctyl)silane on Silicon Dioxide, by XPS
Lee, Michael V.; Husseini, Ghaleb; Sautter, Ken; Linford, Matthew R. (American Vacuum Society, 2012)Monolayers of trichloro(lH,1H,2H,2H-perfluorooctyl)silane, Cl3SiCH2CH2(CF2)5CF3, were deposited via chemical vapor deposition onto the native oxide layer on silicon after plasma-cleaning. The samples have high hydrophobicity, ...