Now showing items 21-40 of 46

    • Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles 

      Husseini, Ghaleb; Rapoport, Natalya Y.; Christensen, Douglas A.; Pruitt, John D.; Pitt, William G. (Elsevier, 2001)
      The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ...
    • Mathematical modeling of microbubble cavitation at 70 kHz and the importance of the subharmonic in drug delivery from micelles 

      Diaz de la Rosa, Mario A.; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2013)
      In order to gain insight into the experimental observation of ultrasound-induced release of drugs from micelles, we modeled the dynamic oscillations of a 10-μm-diameter bubble insonated at 70 kHz. The Parlitz modification ...
    • Micelles and nanoparticles for ultrasonic drug and gene delivery 

      Husseini, Ghaleb; Pitt, William G. (Elsevier, 2008)
      Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues ...
    • Modeling and Sensitivity Analysis of Acoustic Release of Doxorubicin from Unstabilized Pluronic P105 Using an Artificial Neural Network Model 

      Husseini, Ghaleb; Abdel-Jabbar, Nabil; Mjalli, Farouq Sabri; Pitt, William G. (Adenine Press, 2007)
      This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN). Previously collected release data were compiled and used to train, validate, and test ...
    • Non-Viral Gene Transfection with Ultrasound: Is 100% Transfection Possible? 

      Pitt, William G.; Jack, Daniel R.; Husseini, Ghaleb; Memmott, Brett V. (American Scientific Publishers, 2012)
      Ultrasound has been used as a modality to enhance the transfection of cells, purportedly via entry of genetic material through defects in the cell membrane produced by bubble cavitation events. A mathematical model was ...
    • Optimizing the use of ultrasound to deliver chemotherapeutic agents to cancer cells from polymeric micelles 

      Husseini, Ghaleb; Abdel-Jabbar, Nabil; Mjalli, Farouq Sabri; Pitt, William G.; Al-Mousa, Alaa Marwan Subhi (Elsevier, 2011)
      In this study, we present an artificial neural network (ANN) model that attempts to predict the dynamic release of doxorubicin (Dox) from P105 micelles under different ultrasonic power densities at 20 kHz. The goal is to ...
    • Over-Pressure Suppresses Ultrasonic-Induced Drug Uptake 

      Stringham, S. Briant; Viskovska, Maria A.; Richardson, Eric S.; Ohmine, Seiga; Husseini, Ghaleb; Murray, Byron K.; Pitt, William G. (Elseviser, 2008)
      Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer tissues. The present study further examines the role of acoustic cavitation in US-induced permeabilization of cell membranes and subsequent ...
    • Phase transitions of nanoemulsions using ultrasound: Experimental observations 

      Singh, Ram; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2012)
      The ultrasound-induced transformation of perfluorocarbon liquids to gases is of interest in the area of drug and gene delivery. In this study, three independent parameters (temperature, size, and perfluorocarbon species) ...
    • Phase transitions of perfluorocarbon nanoemulsion induced with ultrasound: A mathematical model 

      Pitt, William G.; Singh, Ram; Perez, Krystian X.; Husseini, Ghaleb; Jack, Daniel R. (Elsevier, 2013)
      While ultrasound has been used in many medical and industrial applications, only recently has research been done on phase transformations induced by ultrasound. This paper presents a numerical model and the predicted results ...
    • Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats 

      Pitt, William G.; Husseini, Ghaleb; Roeder, Beverly L.; Dickinson, David J.; Warden, David R.; Hartley, Jonathan M.; Jones, Peter W. (American Scientific Publishers, 2011)
      Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-[carboxy ...
    • Rapid Separation of Bacteria from Blood - Review and Outlook 

      Pitt, William G.; Alizadeh, Mahsa; Husseini, Ghaleb; McClellan, Daniel S.; Buchanan, Clara M.; Bledsoe, Colin G.; Blanco, Rae; Melville, Madison; Hunter, Alex K.; Robison, Richard A.; Roeder, Beverly L. (American Institute of Chemical Engineers (AIChE), 2016)
      The high morbidity and mortality rate of bloodstream infections involving antibiotic‐resistant bacteria necessitate a rapid identification of the infectious organism and its resistance profile. Traditional methods based ...
    • Rapid separation of bacteria from blood – Chemical aspects 

      Alizadeh, Mahsa; Wood, Ryan L.; Buchanan, Clara M.; Bledsoe, Colin G.; Wood, Madison E.; McClellan, Daniel S.; Blanco, Rae; Ravsten, Tanner V.; Husseini, Ghaleb; Hickey, Caroline L.; Robison, Richard A.; Pitt, William G. (Elsevier, 2017)
      To rapidly diagnose infectious organisms causing blood sepsis, bacteria must be rapidly separated from blood, a very difficult process considering that concentrations of bacteria are many orders of magnitude lower than ...
    • Rapid separation of very low concentrations of bacteria from blood 

      Buchanan, Clara M.; Wood, Ryan L.; Hoj, Taalin R.; Alizadeh, Mahsa; Bledsoe, Colin G.; Wood, Madison E.; McClellan, Daniel S.; Blanco, Rae; Hickey, Caroline L.; Ravsten, Tanner V.; Husseini, Ghaleb; Robison, Richard A.; Pitt, William G. (Elsevier, 2017)
      A rapid and accurate diagnosis of the species and antibiotic resistance of bacteria in septic blood is vital to increase survival rates of patients with bloodstream infections, particularly those with carbapenem-resistant ...
    • Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound 

      Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Gabuji, Tasneem; Zeng, Yi; Christensen, Douglas A.; Pitt, William G. (American Scientific Publishers, 2007)
      Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ...
    • The role of cavitation in acoustically activated drug delivery 

      Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Richardson, Eric S.; Christensen, Douglas A.; Pitt, William G. (Elsevier Science Direct, 2005)
      Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from ...
    • Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats 

      Staples, Bryant J.; Roeder, Beverly L.; Husseini, Ghaleb; Badamjav, Odgerel; Schaalje, G. Bruce; Pitt, William G. (Springer, 2009)
      Purpose The therapeutic effect of ultrasound and micellar-encapsulated doxorubicin was studied in vivo using a tumor-bearing rat model with emphasis on how tumor growth rate is affected by ultrasonic parameters such as ...
    • Stabilization of Pluronic P-105 Micelles with an Interpenetrating Network of N,N-Diethylacrylamide 

      Pruitt, John D.; Husseini, Ghaleb; Rapoport, Natalya Y.; Pitt, William G. (American Chemical Society, 2000)
      N,N-Diethylacrylamide (NNDEA) was polymerized in the presence of Pluronic P-105 micelles. The polymerizations resulted in an interpenetrating network of poly(NNDEA) and P-105 that stabilized the micelles at concentrations ...
    • Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide 

      Husseini, Ghaleb; Christensen, Douglas A.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2002)
      Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ...
    • Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment 

      Husseini, Ghaleb; Pitt, William G. (Wiley InterSciences, 2008)
      The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective ...
    • Ultrasonically triggered drug delivery: Breaking the barrier 

      Husseini, Ghaleb; Pitt, William G.; Martins, Ana M. (Elsevier, 2014)
      The adverse side-effects of chemotherapy can be minimized by delivering the therapeutics in time and space to only the desired target site. Ultrasound offers one fairly non-invasive method of accomplishing such precise ...