Browsing Department of Chemical and Biological Engineering by Author "52d629dc-7d2f-47b9-aa2d-258b92e45ae1"
Now showing items 41-60 of 129
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Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy
Ali, Amaal Abdulraqeb; Abuwatfa, Waad Hussein; Al-Sayah, Mohammad; Husseini, Ghaleb (MDPI, 2022)With the urgent need for bio-nanomaterials to improve the currently available cancer treatments, gold nanoparticle (GNP) hybrid nanostructures are rapidly rising as promising multimodal candidates for cancer therapy. Gold ... -
Graphene-based drug delivery systems
Bai, Reenu Geetha; Husseini, Ghaleb (Elsevier, 2019)Drug delivery is one of the prominent biomedical applications of graphene nanomaterials in the current scenario. The rapid growth in the graphene-based drug delivery systems showed the potential of this nanomaterial in the ... -
Growth of 2,2-Biimidazole-Based Nanorods on Mica Substrate
Sowwan, Mukhles; Abul Haj, Mohammad; Faroun, Maryam; Hawash, Zafer; Ghabboun, Jamal; Rida, Alaa; Karmi, Abeer; Sultan, Wadie; Husseini, Ghaleb (Hindawi, 2010)The synthesis of a one-dimensional single-stranded helix using the crystallization of silver (I) nitrate and 2,2-biimidazole has promising potential for use in the area of nanotechnology mainly because of its unique ... -
Hybrid Liposome/Metal–Organic Framework as a Promising Dual-Responsive Nanocarriers for Anticancer Drug Delivery
Karami, Abdollah; Ahmed, Ahmed H.S; Sabouni, Rana; Husseini, Ghaleb; Al Sharabati, Miral Osama Yacoub; AlSawaftah, Nour Majdi; Paul, Vinod (Elsevier, 2022)In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful ... -
Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery
Karami, Abdollah; Ahmed, Ahmed H.S; Sabouni, Rana; Husseini, Ghaleb; Al Sharabati, Miral Osama Yacoub; AlSawaftah, Nour Majdi; Paul, Vinod (Elsevier, 2022)In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful ... -
Identification of Novel MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating the EGFR-ADAM17 Axis: An In Silico Analysis
Mukhopadhyay, Debasmita; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)Cancer patients contracting SARS-CoV-2 encounter additional challenges due to inflammatory bursts and lymphopenia, which may aggravate breast cancer prognosis. In this in-silico analysis, we identified the potential of ... -
Identification of Novel MicroRNAs Targeting SARS-CoV-2 through the Regulation of TMPRSS2/PI3K/AKT/PTEN Alignment in Lung Cancer: An in Silico Analysis
Mukhopadhyay, Debasmita; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)In this study, we investigated the interactions between SARS-CoV-2 and miRNAs associated with lung cancer using bioinformatic approaches. A special focus was placed on TMPRSS2 and lung cancer progression pathways involving ... -
Identification of the Uncertainty Structure to Estimate the Acoustic Release of Chemotherapeutics From Polymeric Micelles
Wadi, Ali; Abdel-Hafez, Mamoun; Husseini, Ghaleb (IEEE, 2017)This paper estimates the acoustic drug release from micelles after accurately identifying the underlying statistical noise characteristics in experimental data. The drug release is measured as a change in fluorescence as ... -
Immunoliposomes: Synthesis, Structure, and Their Potential as Drug Delivery Carriers
Sandeep, Divya; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Bentham Science, 2020)Immunoliposomes have emerged as attractive drug targeting vehicles for cancer treatment. This review presents the recent advances in the design of immunoliposomes encapsulating a variety of chemotherapeutic agents. We ... -
Impact of Ionic Strength and Charge Density on Donnan Potential in the NaCl-Cation Exchange Membrane System
Al-Sakaji, Baraa A. K.; Husseini, Ghaleb; Darwish, Naif (MDPI, 2023)This work aims to theoretically investigate the effect of both the fixed charge density of ion exchange membranes and the ionic strength of the treated aqueous NaCl solution on the generated Donnan potential at thermodynamic ... -
In Vitro Evaluation of Ultrasound Effectiveness in Controlling Doxorubicin Release from Albumin-Conjugated Liposomes
Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Farooq, Afifa; Awad, Nahid S.; Husseini, Ghaleb (American Scientific Publishers, 2022)Functionalized liposomes are among the most promising antineoplastic agents delivery vehicles. Contemporaneous to their accretion at the tumor site, they need to be potentiated to release their cargo using a suitable ... -
Incorporating Computer-Aided Software in the Undergraduate Chemical Engineering Core Courses
Al Naizy, Raafat; Abdel-Jabbar, Nabil; Ibrahim, Taleb; Husseini, Ghaleb (Chemical Engineering Education, 2014)Introductions of computer-aided software and simulators are implemented during the sophomore-year of the chemical engineering (ChE) curriculum at the American University of Sharjah (AUS). Our faculty concurs that software ... -
Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy
AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (Elsevier, 2023)The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the ... -
Intracellular uptake of Pluronic copolymer: effects of the aggregation state
Muniruzzaman, Md.; Marin, Alexander; Luo, Yi; Prestwich, Glenn D.; Pitt, William G.; Husseini, Ghaleb; Rapoport, Natalya Y. (Elsevier, 2002)The effect of the Pluronic P-105 aggregation state on its uptake by HL-60 cells was studied by flow cytometry, fluorescence spectroscopy, and confocal and fluorescence microscopy using a fluorescently labeled Pluronic P105. ... -
Investigating the acoustic release of doxorubicin from targeted micelles
Husseini, Ghaleb; Velluto, Diana; Kherbeck, Laura; Pitt, William G.; Hubbell, Jeffrey A.; Christensen, Douglas A. (Elsevier, 2013)The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable ... -
Investigating the Fluorescence Quenching of Doxorubicin in Folic Acid Solutions and Its Relation to Ligand-Targeted Nanocarriers
Husseini, Ghaleb; Kanan, Sofian; Al-Sayah, Mohammad (American Scientific Publishers, 2015)Folic acid (FA) is one of the most utilized moieties in active (ligand) drug delivery. The folate receptor is widely expressed on the surface of several cell lines and tumors; including ovarian, brain, kidney, breast, and ... -
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
Husseini, Ghaleb; Runyan, Christopher M.; Pitt, William G. (BioMed Central (BMC), 2002)Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and ... -
Investigating the Release Mechanism of Calcein from eLiposomes at Higher Temperatures
Husseini, Ghaleb; Pitt, William G.; Williams, Jacob B; Javadi, Marjan (American Scientific Publishers, 2014)Numerous nanocarriers are currently being investigated as drug delivery vehicles for transporting chemotherapeutics to cancer cells. Our research group has recently synthesized a new generation of echogenic liposomes based ... -
Investigating the Stability of eLiposomes at Elevated Temperatures
Husseini, Ghaleb; Pitt, William G.; Javadi, Marjan (Sage Publishing, 2014)eLiposomes encapsulate a perfluorocarbon nanoemulsion droplet inside a liposome. Ultrasound is then used as a trigger mechanism to vaporize the perfluorocarbon, break the liposome, and release the desired drug to the tumor ... -
Kinetics and thermodynamics of acoustic release of doxorubicin from non-stabilized polymeric micelles
Husseini, Ghaleb; Abouelnasr, Dana; Pitt, William G.; Assaleh, Khaled; Farahat, Lujein O.; Fahadi, Jalal (Elsevier, 2010)This paper studies the thermodynamic characteristics of ultrasound-activated release of Doxorubicin (Dox) from micelles. The release and re-encapsulation of Dox into Pluronic® P105 micelles was measured by recording the ...