Browsing Department of Chemical and Biological Engineering by Author "61c3074c-7e2f-4e84-8097-640a3adbe003"
Now showing items 41-47 of 47
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Technique for Drug and Gene Delivery to the Cell Cytosol
Pitt, William G.; Husseini, Ghaleb (2015-04-07)Provided herein is a composition, a method, and a system for delivering a functional molecule to the cytosol of a cell, comprising a liposome configured to be taken into a cell, including by a process selected from the ... -
Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
Abuwatfa, Waad Hussein; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven ... -
Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review
Kawak, Paul S.; AlSawaftah, Nour Majdi; Pitt, William G.; Husseini, Ghaleb (MDPI, 2026-08-26)Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective ... -
Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide
Husseini, Ghaleb; Christensen, Douglas A.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2002)Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ... -
Ultrasound-Induced Calcein Release From eLiposomes
Lattin, James R.; Pitt, William G.; Belnap, David M.; Husseini, Ghaleb (Elsevier, 2012)Ultrasound is explored as a method of inducing the release of encapsulated materials from eLiposomes, defined as liposomes containing emulsion droplets. Emulsions were formed using perfluorohexane and perfluoropentane. ... -
The Use of Ultrasound and Micelles in Cancer Treatment
Husseini, Ghaleb; Pitt, William G. (American Scientific Publishers, 2008)The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such ... -
Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles
Husseini, Ghaleb; Mjalli, Farouq Sabri; Pitt, William G.; Abdel-Jabbar, Nabil (SAGE Publications, 2009)We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the ...