Now showing items 21-40 of 158

    • The role of cavitation in acoustically activated drug delivery 

      Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Richardson, Eric S.; Christensen, Douglas A.; Pitt, William G. (Elsevier Science Direct, 2005)
      Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from ...
    • Analysis of Sugar Beet Pulp by X-ray Photoelectron Spectroscopy 

      Jiang, Guilin; Husseini, Ghaleb; Baxter, Larry L.; Linford, Matthew R. (American Vacuum Society, 2005)
      Determining the chemical structure and composition of biomass fuels using x-ray photoelectron spectroscopy (XPS) can provide fundamental knowledge of their structures that is useful in understanding and predicting their ...
    • Analysis of Sawdust by X-ray Photoelectron Spectroscopy 

      Jiang, Guilin; Husseini, Ghaleb; Baxter, Larry L.; Linford, Matthew R. (American Vacuum Society, 2005)
      Determining the chemical structure and composition of biomass fuels using x-ray photoelectron spectroscopy (XPS) can provide fundamental knowledge of their structures that is useful in understanding and predicting their ...
    • Analysis of Shea Nut Shells by X-ray Photoelectron Spectroscopy 

      Jiang, Guilin; Husseini, Ghaleb; Baxter, Larry L.; Linford, Matthew R. (American Vacuum Society, 2005)
      Determining the chemical structure and composition of biomass fuels using x-ray photoelectron spectroscopy (XPS) can provide fundamental knowledge of their structures that is useful in understanding and predicting their ...
    • The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 Cells) from Pluronic P105 Micelles 

      Husseini, Ghaleb; O'Neill, Kim L.; Pitt, William G. (Adenine Press, 2005)
      This notes examines the mode of cell death of HL-60 cells exposed to 70 kHz and 1.3 W/cm2 ultrasound in the presence of 1% Pluronic P105 and 1.67 μg/ml doxorubicin (Dox). The cells were ultrasonicated for 30, 60, and 120 ...
    • Analysis of Sunflower Shells by X-ray Photoelectron Spectroscopy 

      Jiang, Guilin; Husseini, Ghaleb; Baxter, Larry L.; Linford, Matthew R. (American Vacuum Society, 2005)
      Determining the chemical structure and composition of biomass fuels using x-ray photoelectron spectroscopy (XPS) can provide fundamental knowledge of their structures that is useful in understanding and predicting their ...
    • Efficient Immobilization of a Cadmium Chemosensor in a Thin Film: Generation of a Cadmium Sensor Prototype 

      Bronson, R. Todd; Michaelis, David J.; Lamb, Randy D.; Husseini, Ghaleb; Farnsworth, Paul B.; Linford, Matthew R.; Izatt, Reed M.; Bradshaw, Jerald S.; Savage, Paul B. (American Chemical Society, 2005)
      The development of an ion-selective chemosensor for Cd2+ allows generation of a “real-time” sensor. Immobilization of the chemosensor on quartz was achieved in a simple monolayer and in a thin film using a polymer intermediary. ...
    • Analysis of Grain Screenings by X-ray Photoelectron Spectroscopy 

      Jiang, Guilin; Husseini, Ghaleb; Baxter, Larry L.; Linford, Matthew R. (American Vacuum Society, 2005)
      Determining the chemical structure and composition of biomass fuels using x-ray photoelectron spectroscopy (XPS) can provide fundamental knowledge of their structures that is useful in understanding and predicting their ...
    • Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models 

      Stevenson-Abouelnasr, Dana; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2006)
      The kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the ...
    • Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound 

      Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Gabuji, Tasneem; Zeng, Yi; Christensen, Douglas A.; Pitt, William G. (American Scientific Publishers, 2007)
      Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ...
    • Modeling and Sensitivity Analysis of Acoustic Release of Doxorubicin from Unstabilized Pluronic P105 Using an Artificial Neural Network Model 

      Husseini, Ghaleb; Abdel-Jabbar, Nabil; Mjalli, Farouq Sabri; Pitt, William G. (Adenine Press, 2007)
      This paper models steady state acoustic release of Doxorubicin (Dox) from Pluronic P105 micelles using Artificial Neural Networks (ANN). Previously collected release data were compiled and used to train, validate, and test ...
    • Ultrasonic-Activated Micellar Drug Delivery for Cancer Treatment 

      Husseini, Ghaleb; Pitt, William G. (Wiley InterSciences, 2008)
      The use of nanoparticles and ultrasound in medicine continues to evolve. Great strides have been made in the areas of producing micelles, nanoemulsions, and solid nanoparticles that can be used in drug delivery. An effective ...
    • The Use of Ultrasound and Micelles in Cancer Treatment 

      Husseini, Ghaleb; Pitt, William G. (American Scientific Publishers, 2008)
      The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such ...
    • Over-Pressure Suppresses Ultrasonic-Induced Drug Uptake 

      Stringham, S. Briant; Viskovska, Maria A.; Richardson, Eric S.; Ohmine, Seiga; Husseini, Ghaleb; Murray, Byron K.; Pitt, William G. (Elseviser, 2008)
      Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer tissues. The present study further examines the role of acoustic cavitation in US-induced permeabilization of cell membranes and subsequent ...
    • Micelles and nanoparticles for ultrasonic drug and gene delivery 

      Husseini, Ghaleb; Pitt, William G. (Elsevier, 2008)
      Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues ...
    • Ultrasound in drug and gene delivery 

      Pitt, William G.; Husseini, Ghaleb (Elsevier, 2008)
      In this issue, we present the current applications and future prospects of ultrasound in various aspects of drug and gene delivery. There are many advantages to ultrasound that make it ideal for the delivery of therapeutics ...
    • Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound 

      Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Dickinson, David J. (Elsevier, 2009)
      The majority of research in the area of acoustically-activated drug delivery from stabilized micelles has been focused on the rapid release of chemotherapy drugs from the core of such nano-carriers. Previous publications ...
    • Using Artificial Neural Networks and Model Predictive Control to Optimize Acoustically Assisted Doxorubicin Release from Polymeric Micelles 

      Husseini, Ghaleb; Mjalli, Farouq Sabri; Pitt, William G.; Abdel-Jabbar, Nabil (SAGE Publications, 2009)
      We have been developing a drug delivery system that uses Pluronic P105 micelles to sequester a chemotherapeutic drug - namely, Doxorubicin (Dox) - until it reaches the cancer site. Ultrasound is then applied to release the ...
    • Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats 

      Staples, Bryant J.; Roeder, Beverly L.; Husseini, Ghaleb; Badamjav, Odgerel; Schaalje, G. Bruce; Pitt, William G. (Springer, 2009)
      Purpose The therapeutic effect of ultrasound and micellar-encapsulated doxorubicin was studied in vivo using a tumor-bearing rat model with emphasis on how tumor growth rate is affected by ultrasonic parameters such as ...
    • Kinetics and thermodynamics of acoustic release of doxorubicin from non-stabilized polymeric micelles 

      Husseini, Ghaleb; Abouelnasr, Dana; Pitt, William G.; Assaleh, Khaled; Farahat, Lujein O.; Fahadi, Jalal (Elsevier, 2010)
      This paper studies the thermodynamic characteristics of ultrasound-activated release of Doxorubicin (Dox) from micelles. The release and re-encapsulation of Dox into Pluronic® P105 micelles was measured by recording the ...