Browsing Department of Chemical Engineering by Issue Date
Now showing items 1-20 of 112
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DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study
(Elsevier, 2000)To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ... -
Factors affecting acoustically triggered release of drugs from polymeric micelles
(Elsevier, 2000)A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ... -
Stabilization of Pluronic P-105 Micelles with an Interpenetrating Network of N,N-Diethylacrylamide
(American Chemical Society, 2000)N,N-Diethylacrylamide (NNDEA) was polymerized in the presence of Pluronic P-105 micelles. The polymerizations resulted in an interpenetrating network of poly(NNDEA) and P-105 that stabilized the micelles at concentrations ... -
Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles
(Elsevier, 2001)The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ... -
Intracellular uptake of Pluronic copolymer: effects of the aggregation state
(Elsevier, 2002)The effect of the Pluronic P-105 aggregation state on its uptake by HL-60 cells was studied by flow cytometry, fluorescence spectroscopy, and confocal and fluorescence microscopy using a fluorescently labeled Pluronic P105. ... -
Ultrasonic release of doxorubicin from Pluronic P105 micelles stabilized with an interpenetrating network of N,N diethylacrylamide
(Elsevier, 2002)Pluronic P105 micelles sequester hydrophobic drugs and release them upon insonation with low frequency ultrasound; however these micelles dissolve relatively quickly upon dilution. The objective of this research was to ... -
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
(BioMed Central (BMC), 2002)Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and ... -
Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake
(Elsevier, 2002)The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant ... -
Alkyl Monolayers on Silica Surfaces Prepared from Neat, Heated ClSi(CH₃)₂(CH₂)₆CH=CH₂ Analyzed by XPS
(American Vacuum Society, 2002)Silane monolayers on silica, prepared from mono-, di-, and trichlorosilanes, are widely used in industry for surface functionalization and modification. However, unlike di-and trichlorosilanes, monochlorosilanes are ... -
Alkyl Monolayers on Silica Surfaces Prepared from Neat, Heated 3-Glycidoxypropyldimethylethoxysilane Analyzed by XPS
(American Vacuum Society, 2002)Silane monolayers on silica, prepared from mono-, di-, and trichlorosilanes, are widely used in industry for surface functionalization and modification. However, unlike di- and trichlorosilanes, monochlorosilanes are ... -
Alkyl Monolayers on Silica Surfaces Prepared from Neat, Heated ClSi(CH₃)₂(CH₂)₁₇CH₃ Analyzed by XPS
(American Vacuum Society, 2002)Silane monolayers on silica, prepared from mono-, di- and trichlorosilanes, are widely used in industry for surface functionalization and modification. However, unlike di- and trichlorosilanes, monochlorosilanes are ... -
Photochemical Lithography: Creation of Patterned, Acid Chloride Functionalized Surfaces Using UV Light and Gas-Phase Oxalyl Chloride
(American Chemical Society, 2003) -
Alkyl Monolayers on Silica Surfaces Prepared Using Neat, Heated Dimethylmonochlorosilanes with Low Vapor Pressures
(American Chemical Society, 2003) -
Self-aligned mechanical attachment of carbon nanotubes to silicon dioxide structures by selective silicon dioxide chemical-vapor deposition
(American Institute of Physics (AIP), 2003)A self-aligned thin-film deposition technique was developed to mechanically attach carbon nanotubes to surfaces for the fabrication of structurally robust nanotube-based nanomechanical devices. Single-walled carbon nanotubes ... -
Rapid and convenient method for preparing masters for microcontact printing with 1–12 mm features
(American Institute of Physics (AIP), 2004)Mechanical scribing can be employed to create surfaces with recessed features. Through replica molding elastomeric copies of these scribed surfaces are created that function as stamps for microcontact printing. It is shown ... -
Alkyl Monolayers on Silica Surfaces Prepared from Neat, Heated (Tridecafluoro-1,1,2,2-tetrahydrooctyl)-1- dimethylchlorosilane Analyzed by XPS
(American Vacuum Society, 2004)Silane monolayers on silica, prepared from mono-, di-, and trichlorosilanes, are widely used in industry for surface functionalization and modification. However, unlike di- and trichlorosilanes, monochlorosilanes are ... -
Analysis of 7,13-Bis((8-hydroxy-2-quinolinyl)methyl)-1,4-dimethyl-1,4,7,13-tetraaza-10-thiacyclopentadecane by XPS
(American Vacuum Society, 2004)Highly toxic metals abound in the environment as a result of pollution. Macrocyclic ligands have been designed that are selective in binding certain toxic metals. This allows for a sensitive means of detecting these poisonous ... -
Analysis of 10,16-Diaza-1,4,7,13-tetrathiacyclooctane-9,17-dione by XPS
(American Vacuum Society, 2004)10,16-Diaza-1,4,7,13-tetrathiacyclooctane-9,17-dione is important for its use as a fluorophoric metal detector. XPS was used to analyze the compound. The compound was mounted on a silicon plate using sticky tape. -
Analysis of 5-chloro-8-methoxy-2-(bromomethyl)quinoline by XPS
(American Vacuum Society, 2004)Macrocyclic ethers are used extensively for their ability to form strong and selective interactions with charged species. It has been shown that the incorporation of heterocyclic groups into macrocylclic ethers increase ... -
The role of cavitation in acoustically activated drug delivery
(Elsevier Science Direct, 2005)Pluronic P105 micelles are potential candidates as chemotherapy drug delivery vehicles using ultrasonic stimulation as a release trigger. Acoustic power has been previously shown to release two anthracycline agents from ...
