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Modeling and Bias-Robust Estimation of the Acoustic Release of Chemotherapeutics from Liposomes
(American Scientific Publishers, 2019)
This paper models the acoustic drug release of chemotherapeutics from liposomes using a kinetic model that accounts for systematic biases affecting the drug delivery process. An optimal stochastic filter is then proposed ...
Ultrasound-Induced Calcein Release From eLiposomes
(Elsevier, 2012)
Ultrasound is explored as a method of inducing the release of encapsulated materials from eLiposomes, defined as liposomes containing emulsion droplets. Emulsions were formed using perfluorohexane and perfluoropentane. ...
Non-Viral Gene Transfection with Ultrasound: Is 100% Transfection Possible?
(American Scientific Publishers, 2012)
Ultrasound has been used as a modality to enhance the transfection of cells, purportedly via entry of genetic material through defects in the cell membrane produced by bubble cavitation events. A mathematical model was ...
Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes
(De Gruyter, 2016)
The use of liposomes as carriers for chemotherapeutic agents in combination with ultrasound as a stimulus to control the time and space of the drug release is a promising approach for cancer treatment, as it can reduce the ...
Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review
(Bentham Science Publishers, 2016)
Anti-neoplastic drugs used for cancer treatment often produce damage to healthy cells, leading to severe side effects in patients undergoing chemotherapy. The encapsulation of these agents in nanoparticles reduces the ...
Measuring the Acoustic Release of a Chemotherapeutic Agent from Folate-Targeted Polymeric Micelles
(American Scientific Publishers, 2018)
In this paper, we compare the use of Bayesian filters for the estimation of release and reencapsulation rates of a chemotherapeutic agent (namely Doxorubicin) from nanocarriers in an acoustically activated drug release ...
Phase transitions of perfluorocarbon nanoemulsion induced with ultrasound: A mathematical model
(Elsevier, 2013)
While ultrasound has been used in many medical and industrial applications, only recently has research been done on phase transformations induced by ultrasound. This paper presents a numerical model and the predicted results ...
Synergistic Nanomedicine: Passive, Active, and Ultrasound-Triggered Drug Delivery in Cancer Treatment
(American Scientific Publishers, 2015)
Nanocarriers are heavily researched as drug delivery vehicles capable of sequestering antineoplastic agents and then releasing their contents at the desired location. The feasibility of using such carriers stems from their ...
Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery
(Bentham Science Publishers, 2019)
Cancer has become one of the most deadly noncommunicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy with low side effects. The most common ...
Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery
(Elsevier, 2010)
Ultrasound (US) increases efficacy of drugs delivered from micelles, but the pharmacokinetics have not been studied previously. In this study, US was used to deliver doxorubicin (Dox) sequestered in micelles in an in vivo ...