• Login
    View Item 
    •   DSpace Home
    • College of Engineering (CEN)
    • Department of Chemical and Biological Engineering
    • View Item
    •   DSpace Home
    • College of Engineering (CEN)
    • Department of Chemical and Biological Engineering
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Synergistic Nanomedicine: Passive, Active, and Ultrasound-Triggered Drug Delivery in Cancer Treatment

    Thumbnail
    View/ Open
    78Review(JNN).pdf (717.9Kb)
    Date
    2015
    Author
    Elkhodiry, Mohamed A.
    Momah, Christian C.
    Suwaidi, Shaima
    Gadalla, Dina
    Martins, Ana M.
    Vitor, Rute F.
    Husseini, Ghaleb
    Advisor(s)
    Unknown advisor
    Type
    Peer-Reviewed
    Article
    Published version
    Metadata
    Show full item record
    Abstract
    Nanocarriers are heavily researched as drug delivery vehicles capable of sequestering antineoplastic agents and then releasing their contents at the desired location. The feasibility of using such carriers stems from their ability to produce a multimodel delivery system whereby passive, ligand and triggered targeting can be applied in the fight against cancer. Passive targeting capitalizes on the leaky nature of tumor tissue which allows for the extravasation of particles with a size smaller than 0.5 m into the tumors. Ligand targeting utilizes the concept of receptor-mediated endocytosis and involves the conjugation of ligands onto the surface of nanoparticles, while triggered targeting involves the use of external and internal stimuli to release the carriers contents upon reaching the diseased location. In this review, micelles and liposomes have been considered due to the promising results they have shown in vivo and in vitro and their potential for advancements into clinical trials. Thus, this review focuses on the most recent advancements in the field of micellar and liposomal drug delivery and considers the synergistic effect of passive- and ligand-targeting strategies, and the use of ultrasound in triggering drug release at the tumor site.
    DSpace URI
    http://hdl.handle.net/11073/19742
    External URI
    https://doi.org/10.1166/jnn.2015.11124
    Collections
    • Department of Chemical and Biological Engineering

    Browse

    All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsCollege/DeptArchive ReferenceSeriesThis CollectionBy Issue DateAuthorsTitlesSubjectsCollege/DeptArchive ReferenceSeries

    My Account

    LoginRegister

    Statistics

    View Usage Statistics

    DSpace software copyright © 2002-2016  DuraSpace
    Submission Policies | Terms of Use | Takedown Policy | Privacy Policy | About Us | Contact Us | Send Feedback

    Return to AUS
    Theme by 
    Atmire NV