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    The Use of Ultrasound and Micelles in Cancer Treatment 

    Husseini, Ghaleb; Pitt, William G. (American Scientific Publishers, 2008)
    The high toxicity of potent chemotherapeutic drugs like Doxorubicin (Dox) limits the therapeutic window in which they can be applied. This window can be expanded by controlling the drug delivery in both space and time such ...
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    Non-Viral Gene Transfection with Ultrasound: Is 100% Transfection Possible? 

    Pitt, William G.; Jack, Daniel R.; Husseini, Ghaleb; Memmott, Brett V. (American Scientific Publishers, 2012)
    Ultrasound has been used as a modality to enhance the transfection of cells, purportedly via entry of genetic material through defects in the cell membrane produced by bubble cavitation events. A mathematical model was ...
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    Release of Doxorubicin from Unstabilized and Stabilized Micelles Under the Action of Ultrasound 

    Husseini, Ghaleb; Diaz de la Rosa, Mario A.; Gabuji, Tasneem; Zeng, Yi; Christensen, Douglas A.; Pitt, William G. (American Scientific Publishers, 2007)
    Polymeric micelles are being investigated as chemotherapy drug delivery carriers using ultrasound as a trigger mechanism. The aim of this paper is to measure the release of Doxorubicin (Dox) from the core of unstabilized ...
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    Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats 

    Pitt, William G.; Husseini, Ghaleb; Roeder, Beverly L.; Dickinson, David J.; Warden, David R.; Hartley, Jonathan M.; Jones, Peter W. (American Scientific Publishers, 2011)
    Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-[carboxy ...
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    Kinetics of Ultrasonic Drug Delivery from Targeted Micelles 

    Husseini, Ghaleb; Kherbeck, Laura; Pitt, William G. (American Scientific Publishers, 2015)
    To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This ...
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    DNA damage induced by micellar-delivered doxorubicin and ultrasound: comet assay study 

    Husseini, Ghaleb; El-Fayoumi, Refaat I.; O'Neill, Kim L.; Rapoport, Natalya Y.; Pitt, William G. (Elsevier, 2000)
    To minimize adverse side effects of chemotherapy, we have developed a micellar drug carrier that retains hydrophobic drugs, and then releases the drug by ultrasonic stimulation. This study investigated the DNA damage induced ...
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    Factors affecting acoustically triggered release of drugs from polymeric micelles 

    Husseini, Ghaleb; Myrup, Gregg D.; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2000)
    A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ...
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    Kinetics of ultrasonic release of doxorubicin from pluronic P105 micelles 

    Husseini, Ghaleb; Rapoport, Natalya Y.; Christensen, Douglas A.; Pruitt, John D.; Pitt, William G. (Elsevier, 2001)
    The aim of this research was to measure and model the kinetics of acoustic release and subsequent re-encapsulation of Doxorubicin (DOX) from Pluronic P105 micelles. A fluorescence detection ultrasound exposure chamber was ...
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    Intracellular uptake of Pluronic copolymer: effects of the aggregation state 

    Muniruzzaman, Md.; Marin, Alexander; Luo, Yi; Prestwich, Glenn D.; Pitt, William G.; Husseini, Ghaleb; Rapoport, Natalya Y. (Elsevier, 2002)
    The effect of the Pluronic P-105 aggregation state on its uptake by HL-60 cells was studied by flow cytometry, fluorescence spectroscopy, and confocal and fluorescence microscopy using a fluorescently labeled Pluronic P105. ...
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    Stabilization of Pluronic P-105 Micelles with an Interpenetrating Network of N,N-Diethylacrylamide 

    Pruitt, John D.; Husseini, Ghaleb; Rapoport, Natalya Y.; Pitt, William G. (American Chemical Society, 2000)
    N,N-Diethylacrylamide (NNDEA) was polymerized in the presence of Pluronic P-105 micelles. The polymerizations resulted in an interpenetrating network of poly(NNDEA) and P-105 that stabilized the micelles at concentrations ...
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    Pitt, William G. (24)
    Husseini, Ghaleb (16)Husseini Ghaleb (7)Christensen, Douglas A. (6)Rapoport, Natalya Y. (6)Diaz de la Rosa, Mario A. (3)Roeder, Beverly L. (3)Dickinson, David J. (2)O'Neill, Kim L. (2)Pruitt, John D. (2)... View MoreSubjectUltrasound (18)Doxorubicin (10)Drug delivery (5)Micellar drug delivery (5)Stabilized micelles (4)Drug Delivery (3)Pluronic (3)Pluronic micelles (3)Polymeric micelles (3)Cancer (2)... View MoreDate Issued2010 - 2015 (6)2000 - 2009 (18)Has File(s)Yes (24)

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