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    Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake

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    Date
    2002
    Author
    Marin, Alexander
    Sun, Hao
    Husseini, Ghaleb
    Pitt, William G.
    Christensen, Douglas A.
    Rapoport, Natalya Y.
    Advisor(s)
    Unknown advisor
    Type
    Peer-Reviewed
    Article
    Postprint
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    Abstract
    The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant (MDR) cells (A2780 and A2780/ADR, respectively), and breast cancer MCF-7 cells. Cavitation events initiated by high-frequency ultrasound were recorded by radical trapping. The onset of transient cavitation and DOX release from micelles were observed at much higher power densities than at low-frequency ultrasound (20–100 kHz). Even a short (15–30 s) exposure to high-frequency ultrasound significantly enhanced the intracellular DOX uptake from PBS, RPMI 1640, and Pluronic micelles. The mechanisms of the observed effects are discussed.
    DSpace URI
    http://hdl.handle.net/11073/21324
    External URI
    https://doi.org/10.1016/s0168-3659(02)00262-6
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