Browsing by Subject "Ultrasound"
Now showing items 21-40 of 71
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Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models
(Elsevier, 2006)The kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the ... -
Hybrid Liposome/Metal–Organic Framework as a Promising Dual-Responsive Nanocarriers for Anticancer Drug Delivery
(Elsevier, 2022)In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful ... -
Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery
(Elsevier, 2022)In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful ... -
Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release
(Bentham Science Publishers, 2018)Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering ... -
In Vitro Cell Work of Two Types of Targeted Nanoparticles with Ultrasound Triggering
(2020-11)Targeted liposomes have shown promising potential as effective chemotherapeutics delivery vehicles in Smart Drug Delivery Systems (SDDSs). Upon accumulation and internalization at the tumor site, the liposomes need to be ... -
Intracellular uptake of Pluronic copolymer: effects of the aggregation state
(Elsevier, 2002)The effect of the Pluronic P-105 aggregation state on its uptake by HL-60 cells was studied by flow cytometry, fluorescence spectroscopy, and confocal and fluorescence microscopy using a fluorescently labeled Pluronic P105. ... -
Investigating the mechanism of acoustically activated uptake of drugs from Pluronic micelles
(BioMed Central (BMC), 2002)Background: This paper examines the mechanism of ultrasonic enhanced drug delivery from Pluronic micelles. In previous publications by our group, fluorescently labeled Pluronic was shown to penetrate HL-60 cells with and ... -
Kinetics of acoustic release of doxorubicin from stabilized and unstabilized micelles and the effect of temperature
(Elsevier, 2011)Ultrasound is being investigated as a trigger mechanism to deliver high concentrations of chemotherapy drugs to cancerous tissues using polymeric micelles. In this paper, we examined the kinetics of acoustic release of ... -
The Kinetics of Calcein Release from Mixed Targeted Liposomes Using Ultrasound
(American Scientific Publishers, 2022)Site-specific delivery of chemotherapeutics using actively targeted-stimuli-responsive liposomes is a promising approach to enhance the therapeutic efficiency of anti-cancer drugs while reducing the associated undesirable ... -
Liposomal drug release using ultrasound and modeling release dynamics for model predictive controller design
(2015-06)Chemotherapy is widely used for cancer treatment; however, it causes unwanted side effects in patients such as fatigue, weight loss, pain, hair fall and nausea. Those side effects are due to the fact that most of the ... -
Liposomal Encapsulation of Chemotherapeutics Agents Combined with the Use of Ultrasound in Cancer Treatment
(American Scientific Publishers, 2023-07)Ultrasound (US) has numerous uses in the medical field, including imaging, tumor ablation, and lithotripsy; another interesting application of US in cancer therapy is as an external trigger in targeted drug delivery. ... -
Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment
(Bentham Science, 2017)The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a ... -
Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery
(Bentham Science Publishers, 2019)Cancer has become one of the most deadly noncommunicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy with low side effects. The most common ... -
Lipsome-coated metal organic frameworks as a new drug nanocarrier
(2019-12)Cancer has emerged to become one of the predominant diseases ever known to humanity, with chemotherapeutic agents as leading methods for treating it. However, this blind-sighted treatment method that targets all cells; ... -
Mathematical modeling of microbubble cavitation at 70 kHz and the importance of the subharmonic in drug delivery from micelles
(Elsevier, 2013)In order to gain insight into the experimental observation of ultrasound-induced release of drugs from micelles, we modeled the dynamic oscillations of a 10-μm-diameter bubble insonated at 70 kHz. The Parlitz modification ... -
Measuring the Acoustic Release of a Chemotherapeutic Agent from Folate-Targeted Polymeric Micelles
(American Scientific Publishers, 2018)In this paper, we compare the use of Bayesian filters for the estimation of release and reencapsulation rates of a chemotherapeutic agent (namely Doxorubicin) from nanocarriers in an acoustically activated drug release ... -
Micelles and nanoparticles for ultrasonic drug and gene delivery
(Elsevier, 2008)Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues ... -
Modeling and Bias-Robust Estimation of the Acoustic Release of Chemotherapeutics from Liposomes
(American Scientific Publishers, 2019)This paper models the acoustic drug release of chemotherapeutics from liposomes using a kinetic model that accounts for systematic biases affecting the drug delivery process. An optimal stochastic filter is then proposed ... -
Modeling of In vitro Release Kinetics of Ultrasound-triggered Targeted Liposomes
(2022-04)Ultrasound-triggered, targeted liposomes are a promising drug delivery system as they potentially improve the clinical outcomes of chemotherapy while reducing associated side effects. However, the common drug release models ... -
Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes
(MDPI, 2022-12-05)Targeted liposomes triggered by ultrasound are a promising drug delivery system as they potentially improve the clinical outcomes of chemotherapy while reducing associated side effects. In this work, a comprehensive model ...