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    The effect of pegylation and targeting moieties on the ultrasound-mediated drug release from liposomes

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    ACS Biomater Sci Eng-Revised-Submitted February 23 2019.pdf (1.143Mb)
    Date
    2019
    Author
    Awad, Nahid S.
    Paul, Vinod
    Mahmoud, Mohamad
    AlSawaftah, Nour Majdi
    Kawak, Paul S.
    Al-Sayah, Mohammad
    Husseini, Ghaleb
    Advisor(s)
    Unknown advisor
    Type
    Article
    Postprint
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    Abstract
    The use of targeted liposomes encapsulating chemotherapy drugs enhances the specific targeting of cancer cells, thus, reducing the side effects of these agents and providing a more patient-friendly treatment. Targeted pegylated (stealth) liposomes have the ability to safely deliver their loaded drugs to the cancer cells by targeting specific receptors overly expressed on the surface of these cells. Applying ultrasound as an external stimulus will safely trigger drug release from these liposomes in a controlled manner. In this study, we investigated the release kinetics of the model drug “calcein” from targeted liposomes sonicated with low-frequency ultrasound (20-kHz). Our results showed that pegylated liposomes were more sonosensitive compared to non-pegylated liposomes. A comparison of the effect of three targeting moieties conjugated to the surface of pegylated liposomes, namely human serum albumin (HSA), transferrin (Tf) and arginylglycylaspartic acid (RGD), on calcein release kinetics was conducted. The fluorescence results showed that HSA-PEG and Tf-PEG liposomes were more sonosensitive (showing higher calcein release following the exposure to pulsed LFUS) compared to the control pegylated liposomes. Thus, adding more acoustic benefits to their targeting efficacy.
    DSpace URI
    http://hdl.handle.net/11073/16542
    External URI
    https://doi.org/10.1021/acsbiomaterials.8b01301
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