College of Engineering (CEN)
Work by the faculty and students of the College of Engineering (CEN)
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Modeling of brain tumors using in vitro, in vivo, and microfluidic models: A review of the current developments
(Elsevier, 2024)Brain cancers are some of the most complex diseases to treat, despite the numerous advances science has made in cancer chemotherapy and research. One of the key obstacles to identifying potential cures for this disease is ... -
Enhancing Curcumin’s therapeutic potential in cancer treatment through ultrasound mediated liposomal delivery
(Nature, 2024)Improving the efficacy of chemotherapy remains a key challenge in cancer treatment, considering the low bioavailability, high cytotoxicity, and undesirable side effects of some clinical drugs. Targeted delivery and sustained ... -
Hybrid liposome/metal–organic framework as a promising dual-responsive nanocarriers for anticancer drug delivery
(Elsevier, 2022)In this work, liposome-coated iron (III) benzene-1,3,5-tricarboxylate (Fe-BTC) metal–organic framework is examined as a promising pH/Ultrasound dual-responsive nanocarriers for doxorubicin (DOX) delivery. The successful ... -
pH and ultrasound dual-responsive drug delivery system based on PEG–folate-functionalized Iron-based metal–organic framework for targeted doxorubicin delivery
(Elsevier, 2021)In recent years, the use of metal–organic frameworks (MOFs) as drug nanocarriers has gained attention because of their extraordinary physical and chemical properties. In this work, dual-responsive iron-based MOFs were ... -
Liposomes as a Promising Ultrasound-Triggered Drug Delivery System in Cancer Treatment
(Bentham Science, 2017)The initial uses of ultrasound waves in the medical field were limited to the thermal ablation of solid tumors and as a diagnostic tool. Recent advances at the preclinical stage have allowed the use of ultrasound as a ... -
Systems and Methods for Targeted Breast Cancer Therapies
(2024-01-09)Systems and methods for producing liposomes, including control liposomes and immunoliposomes targeting breast cancer are provided. Systems and methods for treating breast cancer, using targeted immunoliposomes produced ... -
Systems and Methods for Targeted Breast Cancer Therapies
(2020-12-15)Systems and methods for producing liposomes , including control liposomes and immunoliposomes targeting breast cancer are provided . Systems and methods for treating breast cancer , using targeted immunoliposomes produced ... -
Technique for Drug and Gene Delivery to the Cell Cytosol
(2015-04-07)Provided herein is a composition, a method, and a system for delivering a functional molecule to the cytosol of a cell, comprising a liposome configured to be taken into a cell, including by a process selected from the ... -
State-of-All-the-Art and Prospective Hydrogel-Based Transdermal Drug Delivery Systems
(MDPI, 2024-03-30)Over the past few decades, notable advancements have been made in the field of transdermal drug delivery systems (TDDSs), presenting a promising alternative to conventional oral drug administration. This comprehensive ... -
Nanoparticle-based materials in anticancer drug delivery: Current and future prospects
(Elsevier, 2023)The past decade has witnessed a breakthrough in novel strategies to treat cancer. One of the most common cancer treatment modalities is chemotherapy which involves administering anti-cancer drugs to the body. However, these ... -
Encapsulation and release of calcein from herceptin-conjugated eLiposomes
(Elsevier, 2024-03)Achieving an optimal therapeutic level is crucial in effectively eradicating cancer cells during treatment. However, conventional chemotherapy-associated systemic administration of anticancer agents leads to many side ... -
Scaffold‑based 3D cell culture models in cancer research
(Springer Nature, 2024)Three-dimensional (3D) cell cultures have emerged as valuable tools in cancer research, offering significant advantages over traditional two-dimensional (2D) cell culture systems. In 3D cell cultures, cancer cells are grown ... -
Biodegradable Magnesium Alloys for Biomedical Implants: Properties, Challenges, and Surface Modifications with a Focus on Orthopedic Fixation Repair
(MDPI, 2023-12-19)Biomedical devices made from high-modulus and hardness materials play a critical role in enhancing the quality of life for people with bone-related ailments. While these materials have been successfully used in orthopedic ... -
Two-Stage Deep Learning Solution for Continuous Arabic Sign Language Recognition Using Word Count Prediction and Motion Images
(IEEE, 2023)Recognition of continuous sign language is challenging as the number of words is a sentence and their boundaries are unknown during the recognition stage. This work proposes a two-stage solution in which the number of words ... -
Incorporating nanoparticles in 3D printed scaffolds for bone cancer therapy
(Elsevier, 2023)The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in addition, the surgical resection of bone tumors can cause significant bone defects, further hindering the effective treatment of the ... -
Impact of Ionic Strength and Charge Density on Donnan Potential in the NaCl-Cation Exchange Membrane System
(MDPI, 2023)This work aims to theoretically investigate the effect of both the fixed charge density of ion exchange membranes and the ionic strength of the treated aqueous NaCl solution on the generated Donnan potential at thermodynamic ... -
Effect of phospholipid head group on ultrasound‑triggered drug release and cellular uptake of immunoliposomes
(Nature, 2023)Liposomes are the most successful nanoparticles used to date to load and deliver chemotherapeutic agents to cancer cells. They are nano-sized vesicles made up of phospholipids, and targeting moieties can be added to their ... -
Recent Breakthroughs in Using Quantum Dots for Cancer Imaging and Drug Delivery Purposes
(MDPI, 2023)Cancer is one of the leading causes of death worldwide. Because each person’s cancer may be unique, diagnosing and treating cancer is challenging. Advances in nanomedicine have made it possible to detect tumors and quickly ... -
Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review
(MDPI, 2026-08-26)Glioblastoma (GBM) is a highly aggressive brain tumor, and its treatment is further complicated by the high selectivity of the blood–brain barrier (BBB). The scientific community is urgently seeking innovative and effective ... -
Liposomal Encapsulation of Chemotherapeutics Agents Combined with the Use of Ultrasound in Cancer Treatment
(American Scientific Publishers, 2023-07)Ultrasound (US) has numerous uses in the medical field, including imaging, tumor ablation, and lithotripsy; another interesting application of US in cancer therapy is as an external trigger in targeted drug delivery. ...