Work by the faculty and students of the Department of Chemical Engineering

Recent Submissions

  • Investigating the Release Mechanism of Calcein from eLiposomes at Higher Temperatures 

    Husseini, Ghaleb; Pitt, William G.; Williams, Jacob B; Javadi, Marjan (American Scientific Publishers, 2014)
    Numerous nanocarriers are currently being investigated as drug delivery vehicles for transporting chemotherapeutics to cancer cells. Our research group has recently synthesized a new generation of echogenic liposomes based ...
  • Ultrasound-triggered Release from Micelles 

    Pitt, William G.; Husseini, Ghaleb; Kherbeck, Laura (Royal Society of Chemistry, 2013)
  • Ultrasonic Drug Delivery Using Micelles and Liposomes 

    Martins, Ana M.; Ahmed, Salma E.; Vitor, Rute F.; Husseini, Ghaleb (Springer, 2016)
    The encapsulation of drugs in nanocarriers revolutionized research in drug delivery, especially in cancer chemotherapeutics. Several nanosystems have been developed including liposomes, polymeric micelles, dendrimers, solid ...
  • Green Nanotechnology—A Road Map to Safer Nanomaterials 

    Bai, Reenu Geetha; Sabouni, Rana; Husseini, Ghaleb (Woodhead Publishing, 2018)
    Nanotechnology has remained at the forefront of scientific research for the past few decades due to its outstanding properties and associated applications. The unlimited potential of nanomaterials have already influenced ...
  • Drug delivery in pluronic micelles: effect of high-frequency ultrasound on drug release from micelles and intracellular uptake 

    Marin, Alexander; Sun, Hao; Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Rapoport, Natalya Y. (Elsevier, 2002)
    The effect of high-frequency ultrasound on doxorubicin (DOX) release from Pluronic micelles and intracellular DOX uptake was studied for promyelocytic leukemia HL-60 cells, ovarian carcinoma drug-sensitive and multidrug-resistant ...
  • Multi-Model Investigation and Adaptive Estimation of the Acoustic Release of a Model Drug From Liposomes 

    Wadi, Ali; Abdel-Hafez, Mamoun; Husseini, Ghaleb; Paul, Vinod (IEEE, 2019)
    This paper researches a suitable mathematical model that can reliably predict the release of a model drug (namely calcein) from biologically targeted liposomal nanocarriers triggered by ultrasound. Using mathematical models, ...
  • Factors affecting sedimentational separation of bacteria from blood 

    Pitt, William G.; Alizadeh, Mahsa; Blanco, Rae; Hunter, Alex K.; Bledsoe, Colin G.; McClellan, Daniel S.; Wood, Madison E.; Wood, Ryan L.; Ravsten, Tanner V.; Hickey, Caroline L.; Beard, William Cameron; Stepan, Jacob R.; Carter, Alexandra; Husseini, Ghaleb; Robison, Richard A.; Welling, Evelyn; Torgesen, Rebekah N.; Anderson, Clifton M. (American Institute of Chemical Engineers (AIChE), 2019)
    Rapid diagnosis of blood infections requires fast and efficient separation of bacteria from blood. We have developed spinning hollow disks that separate bacteria from blood cells via the differences in sedimentation ...
  • Liposomes in Active, Passive and Acoustically-Triggered Drug Delivery 

    Al Basha, Sara; Salkho, Najla; Dalibalta, Sarah; Husseini, Ghaleb (Bentham Science Publishers, 2019)
    Cancer has become one of the most deadly noncommunicable diseases globally. Several modalities used to treat cancer patients exist today yet many have failed to prove high efficacy with low side effects. The most common ...
  • Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release 

    Ahmed, Salma E.; Awad, Nahid S.; Paul, Vinod; Moussa, Hesham Gamal; Husseini, Ghaleb (Bentham Science Publishers, 2018)
    Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering ...
  • Identification of the Uncertainty Structure to Estimate the Acoustic Release of Chemotherapeutics From Polymeric Micelles 

    Wadi, Ali; Abdel-Hafez, Mamoun; Husseini, Ghaleb (IEEE, 2017)
    This paper estimates the acoustic drug release from micelles after accurately identifying the underlying statistical noise characteristics in experimental data. The drug release is measured as a change in fluorescence as ...
  • Rapid separation of very low concentrations of bacteria from blood 

    Buchanan, Clara M.; Wood, Ryan L.; Hoj, Taalin R.; Alizadeh, Mahsa; Bledsoe, Colin G.; Wood, Madison E.; McClellan, Daniel S.; Blanco, Rae; Hickey, Caroline L.; Ravsten, Tanner V.; Husseini, Ghaleb; Robison, Richard A.; Pitt, William G. (Elsevier, 2017)
    A rapid and accurate diagnosis of the species and antibiotic resistance of bacteria in septic blood is vital to increase survival rates of patients with bloodstream infections, particularly those with carbapenem-resistant ...
  • Cytosolic Delivery of Doxorubicin from Liposomes to Multidrug-Resistant Cancer Cells via Vaporization of Perfluorocarbon Droplets 

    Williams, Jacob B; Buchanan, Clara M.; Husseini, Ghaleb; Pitt, William G. (MedCrave, 2017)
    A common mechanism of multidrug resistance is the upregulation of efflux pumps in the cancer cells that can more rapidly export unwanted materials (e.g. cancer drugs) out of the cell, compared to sensitive cancer cells. ...
  • Rapid separation of bacteria from blood – Chemical aspects 

    Alizadeh, Mahsa; Wood, Ryan L.; Buchanan, Clara M.; Bledsoe, Colin G.; Wood, Madison E.; McClellan, Daniel S.; Blanco, Rae; Ravsten, Tanner V.; Husseini, Ghaleb; Hickey, Caroline L.; Robison, Richard A.; Pitt, William G. (Elsevier, 2017)
    To rapidly diagnose infectious organisms causing blood sepsis, bacteria must be rapidly separated from blood, a very difficult process considering that concentrations of bacteria are many orders of magnitude lower than ...
  • Use of Model Predictive Control and Artificial Neural Networks to Optimize the Ultrasonic Release of a Model Drug From Liposomes 

    Moussa, Hesham Gamal; Husseini, Ghaleb; Abdel-Jabbar, Nabil; Ahmed, Salma E. (IEEE, 2017)
    The use of echogenic liposomes to deliver chemotherapeutic agents for cancer treatment has gained wide recognition in the last 20 years. Cancerous cells can develop multiple drug resistance (MDR), in part, due to the drop ...
  • Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study 

    Martins, Ana M.; Tanbour, Rafeeq Kamal; Elkhodiry, Mohamed A.; Husseini, Ghaleb (De Gruyter, 2016)
    The aim of this work is to study the kinetics of ultrasound (70 kHz) – using a kinetic model that takes into account cavitation events and drug re-encapsulation upon the cessation of the acoustic field. The simulation ...
  • Anti-cancer Drug Delivery Using Metal Organic Frameworks (MOFs) 

    Ibrahim, Mihad; Sabouni, Rana; Husseini, Ghaleb (Bentham Science Publishers, 2017)
    Cancer is the uncontrolled growth of cells in the body and is considered as one of the major causes of death globally. There are several cytotoxic chemotherapeutic agents used to treat cancer including methotrexate, ...
  • Rapid Separation of Bacteria from Blood - Review and Outlook 

    Pitt, William G.; Alizadeh, Mahsa; Husseini, Ghaleb; McClellan, Daniel S.; Buchanan, Clara M.; Bledsoe, Colin G.; Blanco, Rae; Melville, Madison; Hunter, Alex K.; Robison, Richard A.; Roeder, Beverly L. (American Institute of Chemical Engineers (AIChE), 2016)
    The high morbidity and mortality rate of bloodstream infections involving antibiotic‐resistant bacteria necessitate a rapid identification of the infectious organism and its resistance profile. Traditional methods based ...
  • Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review 

    Tanbour, Rafeeq Kamal; Martins, Ana M.; Pitt, William G.; Husseini, Ghaleb (Bentham Science Publishers, 2016)
    Anti-neoplastic drugs used for cancer treatment often produce damage to healthy cells, leading to severe side effects in patients undergoing chemotherapy. The encapsulation of these agents in nanoparticles reduces the ...
  • Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes 

    Ahmed, Salma E.; Moussa, Hesham Gamal; Martins, Ana M.; Al-Sayah, Mohammad; Husseini, Ghaleb (De Gruyter, 2016)
    The use of liposomes as carriers for chemotherapeutic agents in combination with ultrasound as a stimulus to control the time and space of the drug release is a promising approach for cancer treatment, as it can reduce the ...
  • Review on Triggered Liposomal Drug Delivery with a Focus on Ultrasound 

    Moussa, Hesham Gamal; Martins, Ana M.; Husseini, Ghaleb (Bentham Science Publishers, 2015)
    Chemotherapy is widely used for cancer treatment; however, it causes unwanted side effects in patients. To avoid these adverse effects, nanocarriers have been developed, which can be loaded with the chemotherapeutic agents, ...

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