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dc.contributor.authorAll, Angelo H.
dc.contributor.authorAl-Nashash, Hasan
dc.contributor.authorMir, Hasan
dc.contributor.authorLuo, Shiyu
dc.contributor.authorliu, Xiaogang
dc.date.accessioned2020-02-26T07:55:33Z
dc.date.available2020-02-26T07:55:33Z
dc.date.issued2020
dc.identifier.citationAngelo H. All, Hasan Al Nashash, Hasan Mir, Shiyu Luo, Xiaogang liu, Characterization of transection spinal cord injuries by monitoring somatosensory evoked potentials and motor behavior, Brain Research Bulletin, Volume 156, 2020, Pages 150-163, ISSN 0361-9230, https://doi.org/10.1016/j.brainresbull.2019.12.012.en_US
dc.identifier.issn0361-9230
dc.identifier.urihttp://hdl.handle.net/11073/16636
dc.description.abstractStandardization of spinal cord injury (SCI) models is crucial for reproducible injury in research settings and their objective assessments. Basso, Beattie and Bresnahan (BBB) scoring, the traditional behavioral evaluation method, is subjective and susceptible to human error. On the other hand, neuro-electrophysiological monitoring, such as somatosensory evoked potential (SSEP), is an objective assessment method that can be performed continuously for longitudinal studies. We implemented both SSEP and BBB assessments on transection SCI model. Five experimental groups are designed as follows: left hemi-transection at T8, right hemi-transection at T10, double hemi-transection at left T8 and right T10, complete transection at T8 and control group which receives only laminectomy with intact dura and no injury on spinal cord parenchyma. On days 4, 7, 14 and 21 post-injury, first BBB scores in awake and then SSEP signals in anesthetized rats were obtained. Our results show SSEP signals and BBB scores are both closely associated with transection model and injury progression. However, the two assessment modalities demonstrate different sensitivity in measuring injury progression when it comes to late-stage double hemi-transection, complete transection and hemi-transection injury. Furthermore, SSEP amplitudes are found to be distinct in different injury groups and the progress of their attenuation is increasingly rapid with more severe transection injuries. It is evident from our findings that SSEP and BBB methods provide distinctive and valuable information and could be complementary of each other. We propose incorporating both SSEP monitoring and conventional BBB scoring in SCI research to more effectively standardize injury progression.en_US
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.urihttps://doi.org/10.1016/j.brainresbull.2019.12.012en_US
dc.subjectTransectionen_US
dc.subjectSpinal cord injuryen_US
dc.subjectSomatosensory evoked potentialen_US
dc.subjectSSEPen_US
dc.subjectBBB scoreen_US
dc.subjectRaten_US
dc.titleCharacterization of transection spinal cord injuries by monitoring somatosensory evoked potentials and motor behavioren_US
dc.typePeer-Revieweden_US
dc.typeArticleen_US
dc.typePostprinten_US
dc.identifier.doi10.1016/j.brainresbull.2019.12.012en_US


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