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    Bioluminescence Imaging Applications in Cancer: A Comprehensive Review

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    RBME2995124.pdf (1.386Mb)
    Date
    2020
    Author
    AlSawaftah, Nour Majdi
    Farooq, Afifa
    Dhou, Salam
    Majdalawieh, Amin
    Advisor(s)
    Unknown advisor
    Type
    Peer-Reviewed
    Article
    Published version
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    Abstract
    Bioluminescence imaging (BLI), an optical preclinical imaging modality, is an invaluable imaging modality due to its low-cost, high throughput, fast acquisition times, and functional imaging capabilities. BLI is being extensively used in the field of cancer imaging, especially with the recent developments in genetic-engineering, stem cell, and gene therapy treatments. The purpose of this paper is to provide a comprehensive review of the principles, developments, and current status of BLI in cancer research. This paper covers the fundamental BLI concepts including BLI reporters and enzyme-substrate systems, data acquisition, and image characteristics. It reviews the studies discussing the use of BLI in cancer research such as imaging tumor-characteristic phenomena including tumorigenesis, metastasis, cancer metabolism, apoptosis, hypoxia, and angiogenesis, and response to cancer therapy treatments including chemotherapy, radiotherapy, immunotherapy, gene therapy, and stem cell therapy. The key advantages and disadvantages of BLI compared to other common imaging modalities are also discussed.
    DSpace URI
    http://hdl.handle.net/11073/16673
    External URI
    http://dx.doi.org/10.1109/RBME.2020.2995124
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    • Department of Computer Science and Engineering

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