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    The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes

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    35Review(JDT).pdf (5.106Mb)
    Date
    2014
    Author
    Ahmed, Salma E.
    Martins, Ana M.
    Husseini, Ghaleb
    Advisor(s)
    Unknown advisor
    Type
    Peer-Reviewed
    Article
    Postprint
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    Abstract
    Several drug delivery systems have been investigated to reduce the side effects of chemotherapy by encapsulating the therapeutic agent in a nanosized carrier until it reaches the tumor site. Many of these particles are designed to be responsive to the mechanical and thermal perturbations delivered by ultrasound. Once the nanoparticle reaches the desired location, ultrasound is applied to release the chemotherapy drug only in the vicinity of the targeted (cancer) site, thus avoiding any detrimental interaction with healthy cells in the body. Studies using liposomes and micelles have shown promising results in this area, as these nanoparticles with simple, yet effective structures, showed high efficiency as drug delivery vehicles both in vitro and in vivo. This article reviews the design and application of two novel nanosized chemotherapeutic carriers (i.e. micelles and liposomes) intended to be actuated by ultrasound.
    DSpace URI
    http://hdl.handle.net/11073/21302
    External URI
    https://doi.org/10.3109/1061186X.2014.954119
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