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    Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation

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    Whole Organism Model to Study Molecular Mechanisms of Differentiation and Dedifferentiation.pdf (325.5Kb)
    Date
    2020
    Author
    Anwar, Areeba
    Siddiqui, Ruqaiyyah
    Khan, Naveed
    Advisor(s)
    Unknown advisor
    Type
    Peer-Reviewed
    Article
    Published version
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    Abstract
    Cancer recurrence has remained a significant challenge, despite advances in therapeutic approaches. In part, this is due to our incomplete understanding of the biology of cancer stem cells and the underlying molecular mechanisms. The phenomenon of differentiation and dedifferentiation (phenotypic switching) is not only unique to stem cells but it is also observed in several other organisms, as well as evolutionary-related microbes. Here, we propose the use of a primitive eukaryotic unicellular organism, Acanthamoeba castellanii, as a model to study the molecular mechanisms of cellular differentiation and dedifferentiation.
    DSpace URI
    http://hdl.handle.net/11073/21416
    External URI
    https://doi.org/10.3390/biology9040079
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