Browsing Department of Biology, Chemistry and Environmental Sciences by Issue Date
Now showing items 1-20 of 88
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The Role of AEBP1 in Sex-Specific Diet-Induced Obesity
(Springer Nature, 2005)Obesity is an important risk factor for heart disease, diabetes, and certain cancers, but the molecular basis for obesity is poorly understood. The transcriptional repressor AEBP₁, which functions as a negative regulator ... -
Anti-bacterial self-assembled nanotubes of cyclic d, l-alpha-peptides
(AIP Publishing, 2007)Cyclic D, L‐α‐peptides can be designed to spontaneously partition into lipid and cell membranes where they self‐assemble into membrane‐permeating nanotubes and result in disruption of membrane potentials leading to rapid ... -
Adipocyte Enhancer-binding Protein-1 Promotes Macrophage Inflammatory Responsiveness by Up-Regulating NF-κB via IκBα Negative Regulation
(The American Society for Cell Biology, 2007)Nuclear factor κB (NF-κB) subunits comprise a family of eukaryotic transcription factors that are critically involved in cell proliferation, inflammation, and apoptosis. Under basal conditions, NF-κB subunits are kept under ... -
The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARγ-dependent and PPARγ-independent mechanisms
(Elsevier, 2008)The adipocyte-derived secretory protein adiponectin functions as an insulin-sensitizing agent. In plasma, adiponectin exists as low, medium, and high molecular weight oligomers. Treatment with trans-10, cis-12 conjugated ... -
Regulation of I𝜅B𝛼 Function and NF-𝜅B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages
(Hindawi, 2010)NF-𝜅B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-𝜅B in inflammation and atherosclerosis and the regulation of the NF-𝜅B ... -
PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
(Sage, 2010)Peroxisome proliferator-activated receptor γ1 (PPARγ1) and liver X receptor α (LXRα) are nuclear receptors that play pivotal roles in macrophage cholesterol homeostasis and inflammation; key biological processes in ... -
Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mice
(Springer Nature, 2011)Atherogenesis is a long-term process that involves inflammatory response coupled with metabolic dysfunction. Foam cell formation and macrophage inflammatory response are two key events in atherogenesis. Adipocyte ... -
Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice
(Public Library of Science, 2011)Adipocyte enhancer binding protein 1 (AEBP1) is a multifunctional protein that negatively regulates the tumor suppressor PTEN and IκBα, the inhibitor of NF-κB, through protein-protein interaction, thereby promoting cell ... -
A Density Functional Theory Study of the Cu⁺ · O₂ and Cu⁺ · N₂ Adducts
(De Gruyter, 2011)The geometries and harmonic vibration frequencies of the Cu⁺·O₂ and Cu⁺ ·N₂ are determined by various density functional theory (DFT) methods employing different basis sets. The potential energy surfaces (PES) are examined. ... -
Stromal Adipocyte Enhancer-binding Protein (AEBP1) Promotes Mammary Epithelial Cell Hyperplasia via Proinflammatory and Hedgehog Signaling
(Elsevier, 2012)Disruption of mammary stromal-epithelial communication leads to aberrant mammary gland development and induces mammary tumorigenesis. Macrophages have been implicated in carcinogenesis primarily by creating an inflammatory ... -
Novel algorithms for accurate DNA base-calling
(Scientific Research Publishing, 2013)The ability to decipher the genetic code of different species would lead to significant future scientific achievements in important areas, including medicine and agriculture. The importance of DNA sequencing necessitated ... -
Evaluation of the interaction potential of synthetic ethylene glycol compounds with nuclear Factor κB
(PKP, 2013)In the last three decades, nuclear factor κB (NF-κB) has been the focus of many researchers who are interested in understanding the various molecular mechanisms involved in inflammatory diseases and cancer. Interference ... -
Utilizing active learning strategies to enhance learning in first year university chemistry courses
(Zayed University Press, 2013)Teaching chemistry to non-science majors can be a challenge in higher education owing to students’ perceptions of the subject’s difficulty, and of its usefulness. In order to address these challenges, the authors applied ... -
Effect of pH, ultrasound frequency and power density on the release of calcein from stealth liposomes
(De Gruyter, 2016)The use of liposomes as carriers for chemotherapeutic agents in combination with ultrasound as a stimulus to control the time and space of the drug release is a promising approach for cancer treatment, as it can reduce the ... -
Recent advances on the anti-cancer properties of Nigella sativa, a widely used food additive
(Elsevier, 2016)The use of naturally-occurring agents to regulate tumorigenesis is on the rise. Several herbal extracts, pure plant-derived active constituents, and food additives have been reported to possess potent anti-cancer properties ... -
Preparation and characterization of gatifloxacin-loaded sodium alginate hydrogel membranes supplemented with hydroxypropyl methylcellulose and hydroxypropyl cellulose polymers for wound dressing
(PKP, 2016)Introduction: The aim of this study is to evaluate gatifloxacin-loaded sodium alginate hydrogel membranes, supplemented with glycerol (a plasticizer), glutaraldehyde (a cross-linking agent), and hydroxypropyl methylcellulose ... -
Efficient and simple protocol employing borohydride systems to design a selective osthol-zirconium (OST-Zr) library from potential natural products
(PKP, 2016)“Drug likeness” of a molecule is the prime criterion for a molecule to exhibit the desired pharmaceutical activity. A pharmacophore, which describes molecular features that are necessary for molecular recognition of a ... -
Anti-Bacterial and Anti-Fungal Activity of Xanthones Obtained via Semi-Synthetic Modification of α-Mangostin from Garcinia mangostana
(MDPI, 2017)The microbial contamination in food packaging has been a major concern that has paved the way to search for novel, natural anti-microbial agents, such as modified α-mangostin. In the present study, twelve synthetic analogs ... -
Drivers and challenges for implementing ISO 14001 environmental management systems in an emerging Gulf Arab country
(Springer, 2017-11-13)Worldwide, ISO 14001 certification for organizations has become the norm, but the Arab world accounts for an insignificant portion of all the certified organizations. There is a dearth of research on environmental management ... -
Mechanical and phytochemical protection mechanisms of Calligonum comosum in arid deserts
(Public Library of Science, 2018)Unlike animals, plants are sessile organisms, lacking circulating antibodies and specialized immune cells and are exposed to various harsh environmental conditions that make them at risk of being attacked by different ...