Browsing Department of Biology, Chemistry and Environmental Sciences by Author "633ff4d4-9283-49b7-960e-e9abf03f0a7b"
Now showing items 1-9 of 9
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Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mice
Bogachev, Oleg; Majdalawieh, Amin; Pan, Xuefang; Zhang, Lei; Ro, Hyo-Sung (Springer Nature, 2011)Atherogenesis is a long-term process that involves inflammatory response coupled with metabolic dysfunction. Foam cell formation and macrophage inflammatory response are two key events in atherogenesis. Adipocyte ... -
Adipocyte Enhancer-binding Protein-1 Promotes Macrophage Inflammatory Responsiveness by Up-Regulating NF-κB via IκBα Negative Regulation
Majdalawieh, Amin; Zhang, Lei; Ro, Hyo-Sung (The American Society for Cell Biology, 2007)Nuclear factor κB (NF-κB) subunits comprise a family of eukaryotic transcription factors that are critically involved in cell proliferation, inflammation, and apoptosis. Under basal conditions, NF-κB subunits are kept under ... -
AEBP1 is a Novel Oncogene: Mechanisms of Action and Signaling Pathways
Majdalawieh, Amin; Massri, Mariam; Ro, Hyo-Sung (Hindawi, 2020)Adipocyte enhancer-binding protein 1 (AEBP1) is a transcriptional repressor involved in the regulation of critical biological processes including adipogenesis, mammary gland development, inflammation, macrophage cholesterol ... -
Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice
Zhang, Lei; Reidy, Shannon P.; Bogachev, Oleg; Hall, Brian K.; Majdalawieh, Amin; Ro, Hyo-Sung (Public Library of Science, 2011)Adipocyte enhancer binding protein 1 (AEBP1) is a multifunctional protein that negatively regulates the tumor suppressor PTEN and IκBα, the inhibitor of NF-κB, through protein-protein interaction, thereby promoting cell ... -
PPARγ1 and LXRα face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1
Majdalawieh, Amin; Ro, Hyo-Sung (Sage, 2010)Peroxisome proliferator-activated receptor γ1 (PPARγ1) and liver X receptor α (LXRα) are nuclear receptors that play pivotal roles in macrophage cholesterol homeostasis and inflammation; key biological processes in ... -
Regulation of I𝜅B𝛼 Function and NF-𝜅B Signaling: AEBP1 Is a Novel Proinflammatory Mediator in Macrophages
Majdalawieh, Amin; Ro, Hyo-Sung (Hindawi, 2010)NF-𝜅B comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-𝜅B in inflammation and atherosclerosis and the regulation of the NF-𝜅B ... -
The Role of AEBP1 in Sex-Specific Diet-Induced Obesity
Zhang, Lei; Reidy, Shannon P.; Nicholson, Tara E.; Lee, Hyun-Jeong; Majdalawieh, Amin; Webber, Chris; Stewart, Bruce R.; Dolphin, Peter; Ro, Hyo-Sung (Springer Nature, 2005)Obesity is an important risk factor for heart disease, diabetes, and certain cancers, but the molecular basis for obesity is poorly understood. The transcriptional repressor AEBP₁, which functions as a negative regulator ... -
Stromal Adipocyte Enhancer-binding Protein (AEBP1) Promotes Mammary Epithelial Cell Hyperplasia via Proinflammatory and Hedgehog Signaling
Holloway, Ryan W.; Bogachev, Oleg; Bharadwaj, Alamelu G.; McCluske, Greg D.; Majdalawieh, Amin; Zhang, Lei; Ro, Hyo-Sung (Elsevier, 2012)Disruption of mammary stromal-epithelial communication leads to aberrant mammary gland development and induces mammary tumorigenesis. Macrophages have been implicated in carcinogenesis primarily by creating an inflammatory ... -
The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARγ-dependent and PPARγ-independent mechanisms
Miller, Jessica R.; Siripurkpong, Pilaiwan; Hawes, Jennifer; Majdalawieh, Amin; Ro, Hyo-Sung; McLeod, Roger S. (Elsevier, 2008)The adipocyte-derived secretory protein adiponectin functions as an insulin-sensitizing agent. In plasma, adiponectin exists as low, medium, and high molecular weight oligomers. Treatment with trans-10, cis-12 conjugated ...