Browsing Department of Biology, Chemistry and Environmental Sciences by Author "741ec8bd-9110-414d-adfd-c69ffe33c74b"
Now showing items 1-3 of 3
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Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mice
Bogachev, Oleg; Majdalawieh, Amin; Pan, Xuefang; Zhang, Lei; Ro, Hyo-Sung (Springer Nature, 2011)Atherogenesis is a long-term process that involves inflammatory response coupled with metabolic dysfunction. Foam cell formation and macrophage inflammatory response are two key events in atherogenesis. Adipocyte ... -
Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice
Zhang, Lei; Reidy, Shannon P.; Bogachev, Oleg; Hall, Brian K.; Majdalawieh, Amin; Ro, Hyo-Sung (Public Library of Science, 2011)Adipocyte enhancer binding protein 1 (AEBP1) is a multifunctional protein that negatively regulates the tumor suppressor PTEN and IκBα, the inhibitor of NF-κB, through protein-protein interaction, thereby promoting cell ... -
Stromal Adipocyte Enhancer-binding Protein (AEBP1) Promotes Mammary Epithelial Cell Hyperplasia via Proinflammatory and Hedgehog Signaling
Holloway, Ryan W.; Bogachev, Oleg; Bharadwaj, Alamelu G.; McCluske, Greg D.; Majdalawieh, Amin; Zhang, Lei; Ro, Hyo-Sung (Elsevier, 2012)Disruption of mammary stromal-epithelial communication leads to aberrant mammary gland development and induces mammary tumorigenesis. Macrophages have been implicated in carcinogenesis primarily by creating an inflammatory ...