Browsing Department of Biology, Chemistry and Environmental Sciences by Author "e96ea22b-f441-45a9-93b2-b59aa737eaf7"
Now showing items 1-5 of 5
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Adipocyte Enhancer-Binding Protein 1 (AEBP1) (a Novel Macrophage Proinflammatory Mediator) Overexpression Promotes and Ablation Attenuates Atherosclerosis in ApoE⁻′⁻ and LDLR⁻′⁻ Mice
Bogachev, Oleg; Majdalawieh, Amin; Pan, Xuefang; Zhang, Lei; Ro, Hyo-Sung (Springer Nature, 2011)Atherogenesis is a long-term process that involves inflammatory response coupled with metabolic dysfunction. Foam cell formation and macrophage inflammatory response are two key events in atherogenesis. Adipocyte ... -
Adipocyte Enhancer-binding Protein-1 Promotes Macrophage Inflammatory Responsiveness by Up-Regulating NF-κB via IκBα Negative Regulation
Majdalawieh, Amin; Zhang, Lei; Ro, Hyo-Sung (The American Society for Cell Biology, 2007)Nuclear factor κB (NF-κB) subunits comprise a family of eukaryotic transcription factors that are critically involved in cell proliferation, inflammation, and apoptosis. Under basal conditions, NF-κB subunits are kept under ... -
Lactation Defect with Impaired Secretory Activation in AEBP1-Null Mice
Zhang, Lei; Reidy, Shannon P.; Bogachev, Oleg; Hall, Brian K.; Majdalawieh, Amin; Ro, Hyo-Sung (Public Library of Science, 2011)Adipocyte enhancer binding protein 1 (AEBP1) is a multifunctional protein that negatively regulates the tumor suppressor PTEN and IκBα, the inhibitor of NF-κB, through protein-protein interaction, thereby promoting cell ... -
The Role of AEBP1 in Sex-Specific Diet-Induced Obesity
Zhang, Lei; Reidy, Shannon P.; Nicholson, Tara E.; Lee, Hyun-Jeong; Majdalawieh, Amin; Webber, Chris; Stewart, Bruce R.; Dolphin, Peter; Ro, Hyo-Sung (Springer Nature, 2005)Obesity is an important risk factor for heart disease, diabetes, and certain cancers, but the molecular basis for obesity is poorly understood. The transcriptional repressor AEBP₁, which functions as a negative regulator ... -
Stromal Adipocyte Enhancer-binding Protein (AEBP1) Promotes Mammary Epithelial Cell Hyperplasia via Proinflammatory and Hedgehog Signaling
Holloway, Ryan W.; Bogachev, Oleg; Bharadwaj, Alamelu G.; McCluske, Greg D.; Majdalawieh, Amin; Zhang, Lei; Ro, Hyo-Sung (Elsevier, 2012)Disruption of mammary stromal-epithelial communication leads to aberrant mammary gland development and induces mammary tumorigenesis. Macrophages have been implicated in carcinogenesis primarily by creating an inflammatory ...