Browsing Department of Chemical and Biological Engineering by Subject "Drug release"

Now showing items 1-8 of 8

    • Degradation kinetics of stabilized Pluronic micelles under the action of ultrasound 

      Husseini, Ghaleb; Pitt, William G.; Christensen, Douglas A.; Dickinson, David J. (Elsevier, 2009)
      The majority of research in the area of acoustically-activated drug delivery from stabilized micelles has been focused on the rapid release of chemotherapy drugs from the core of such nano-carriers. Previous publications ...

    • Drug Delivery Systems Based on Polymeric Micelles and Ultrasound: A Review 

      Tanbour, Rafeeq Kamal; Martins, Ana M.; Pitt, William G.; Husseini, Ghaleb (Bentham Science Publishers, 2016)
      Anti-neoplastic drugs used for cancer treatment often produce damage to healthy cells, leading to severe side effects in patients undergoing chemotherapy. The encapsulation of these agents in nanoparticles reduces the ...

    • Investigating the acoustic release of doxorubicin from targeted micelles 

      Husseini, Ghaleb; Velluto, Diana; Kherbeck, Laura; Pitt, William G.; Hubbell, Jeffrey A.; Christensen, Douglas A. (Elsevier, 2013)
      The main problem associated with the administration of anti-cancer medication is that the drug is delivered throughout the body causing undesirable side effects. Therefore, it is important to synthesize drug carriers capable ...

    • Modeling of the In Vitro Release Kinetics of Sonosensitive Targeted Liposomes 

      Almajed, Zeyad Mohamed; Salkho, Najla; Sulieman, Hana; Husseini, Ghaleb (MDPI, 2022-12-05)
      Targeted liposomes triggered by ultrasound are a promising drug delivery system as they potentially improve the clinical outcomes of chemotherapy while reducing associated side effects. In this work, a comprehensive model ...

    • Optimizing the use of ultrasound to deliver chemotherapeutic agents to cancer cells from polymeric micelles 

      Husseini, Ghaleb; Abdel-Jabbar, Nabil; Mjalli, Farouq Sabri; Pitt, William G.; Al-Mousa, Alaa Marwan Subhi (Elsevier, 2011)
      In this study, we present an artificial neural network (ANN) model that attempts to predict the dynamic release of doxorubicin (Dox) from P105 micelles under different ultrasonic power densities at 20 kHz. The goal is to ...

    • Predicting the Release of Chemotherapeutics From the Core of Polymeric Micelles Using Ultrasound 

      Abdel-Hafez, Mamoun; Husseini, Ghaleb (IEEE Explore, 2015)
      In this paper, the estimation of acoustic drug release from micelles is addressed. The release is measured as a decrease in fluorescence once ultrasound is applied. Initially, a Kalman filter is used to fuse the drug ...

    • Recent Advances in Metal-Organic Frameworks as Anticancer Drug Delivery Systems: A Review 

      Karami, Abdollah; Mohamed, Omnia A.; Ahmed, Ahmed H.S; Husseini, Ghaleb; Sabouni, Rana (Bentham, 2021)
      Background: Metal-organic frameworks (MOFs), as attractive hybrid crystalline porous materials, are increasingly being investigated in biomedical applications owing to their exceptional properties, including high porosity, ...

    • Ultrasound-responsive Nanocarriers in Cancer Treatment: a review 

      Awad, Nahid S.; Paul, Vinod; Haar, Gail ter; Allen, Theresa M.; Pitt, William G.; AlSawaftah, Nour Majdi; Husseini, Ghaleb (American Chemical Society, 2021)
      The safe and effective delivery of anticancer agents to diseased tissues is one of the significant challenges in cancer therapy. Conventional anticancer agents are generally cytotoxins with poor pharmacokinetics and ...