Now showing items 1-20 of 32

    • Alkyl Monolayers on Silica Surfaces Prepared from Neat, Heated ClSi(CH₃)₂(CH₂)₁₇CH₃ Analyzed by XPS 

      Husseini, Ghaleb; Zilch, Lloyd W.; Sevy, Eric T.; Asplund, Matthew C.; Linford, Matthew R. (American Vacuum Society, 2002)
      Silane monolayers on silica, prepared from mono-, di- and trichlorosilanes, are widely used in industry for surface functionalization and modification. However, unlike di- and trichlorosilanes, monochlorosilanes are ...
    • Analysis of 7,13-Bis((8-hydroxy-2-quinolinyl)methyl)-1,4-dimethyl-1,4,7,13-tetraaza-10-thiacyclopentadecane by XPS 

      Hoggard, Jamin; Carlson, Eric D.; Frederickson, Scott H.; Monson, Chris F.; Gertsch, Kevin R; Bronson, R. Todd; Savage, Paul B.; Linford, Matthew R.; Husseini, Ghaleb (American Vacuum Society, 2004)
      Highly toxic metals abound in the environment as a result of pollution. Macrocyclic ligands have been designed that are selective in binding certain toxic metals. This allows for a sensitive means of detecting these poisonous ...
    • Analysis of Sunflower Shells by X-ray Photoelectron Spectroscopy 

      Jiang, Guilin; Husseini, Ghaleb; Baxter, Larry L.; Linford, Matthew R. (American Vacuum Society, 2005)
      Determining the chemical structure and composition of biomass fuels using x-ray photoelectron spectroscopy (XPS) can provide fundamental knowledge of their structures that is useful in understanding and predicting their ...
    • Block copolymer micelles as long-circulating drug delivery vehicles 

      Abuwatfa, Waad Hussein; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Elsevier, 2022)
      Medical applications of nanotechnology have attracted growing interest in recent years, particularly in the field of drug delivery, because of nanotechnology’s ability to overcome the limitations of existing treatment ...
    • The Comet Assay to Determine the Mode of Cell Death for the Ultrasonic Delivery of Doxorubicin to Human Leukemia (HL-60 Cells) from Pluronic P105 Micelles 

      Husseini, Ghaleb; O'Neill, Kim L.; Pitt, William G. (Adenine Press, 2005)
      This notes examines the mode of cell death of HL-60 cells exposed to 70 kHz and 1.3 W/cm2 ultrasound in the presence of 1% Pluronic P105 and 1.67 μg/ml doxorubicin (Dox). The cells were ultrasonicated for 30, 60, and 120 ...
    • The effect of pegylation and targeting moieties on the ultrasound-mediated drug release from liposomes 

      Awad, Nahid S.; Paul, Vinod; Mahmoud, Mohamad; AlSawaftah, Nour Majdi; Kawak, Paul S.; Al-Sayah, Mohammad; Husseini, Ghaleb (ACS Publications, 2019)
      The use of targeted liposomes encapsulating chemotherapy drugs enhances the specific targeting of cancer cells, thus, reducing the side effects of these agents and providing a more patient-friendly treatment. Targeted ...
    • Efficient Immobilization of a Cadmium Chemosensor in a Thin Film: Generation of a Cadmium Sensor Prototype 

      Bronson, R. Todd; Michaelis, David J.; Lamb, Randy D.; Husseini, Ghaleb; Farnsworth, Paul B.; Linford, Matthew R.; Izatt, Reed M.; Bradshaw, Jerald S.; Savage, Paul B. (American Chemical Society, 2005)
      The development of an ion-selective chemosensor for Cd2+ allows generation of a “real-time” sensor. Immobilization of the chemosensor on quartz was achieved in a simple monolayer and in a thin film using a polymer intermediary. ...
    • Facile Ultrasound-Triggered Release of Calcein and Doxorubicin from Iron-Based Metal-Organic Frameworks 

      Ibrahim, Mihad; Sabouni, Rana; Husseini, Ghaleb; Karami, Abdollah; Bai, Reenu Geetha; Mukhopadhyay, Debasmita (American Scientific Publishers, 2020)
      Metal-organic frameworks (MOFs) are promising new nanocarriers with potential use in anticancer drug delivery. However, there is a scarcity of studies on the uptake and release of guest molecules associated with MOF ...
    • Further investigation of the mechanism of Doxorubicin release from P105 micelles using kinetic models 

      Stevenson-Abouelnasr, Dana; Husseini, Ghaleb; Pitt, William G. (Elsevier, 2006)
      The kinetics of the release of Doxorubicin from Pluronic P105 micelles during ultrasonication and its subsequent re-encapsulation upon cessation of insonation were investigated. Four mechanisms are proposed to explain the ...
    • Green Nanotechnology—A Road Map to Safer Nanomaterials 

      Bai, Reenu Geetha; Sabouni, Rana; Husseini, Ghaleb (Woodhead Publishing, 2018)
      Nanotechnology has remained at the forefront of scientific research for the past few decades due to its outstanding properties and associated applications. The unlimited potential of nanomaterials have already influenced ...
    • Improving the Efficacy of Anticancer Drugs via Encapsulation and Acoustic Release 

      Ahmed, Salma E.; Awad, Nahid S.; Paul, Vinod; Moussa, Hesham Gamal; Husseini, Ghaleb (Bentham Science Publishers, 2018)
      Conventional chemotherapeutics lack the specificity and controllability, thus may poison healthy cells while attempting to kill cancerous ones. Newly developed nano-drug delivery systems have shown promise in delivering ...
    • Kinetics of Ultrasonic Drug Delivery from Targeted Micelles 

      Husseini, Ghaleb; Kherbeck, Laura; Pitt, William G.; Christensen, Douglas A.; Velluto, Diana (American Scientific Publishers, 2015)
      To minimize the adverse side effects of conventional chemotherapy, a targeted micellar drug carrier was investigated that retains hydrophobic drugs in its core and then releases the drug via ultrasonic activation. This ...
    • Micelles and nanoparticles for ultrasonic drug and gene delivery 

      Husseini, Ghaleb; Pitt, William G. (Elsevier, 2008)
      Drug delivery research employing micelles and nanoparticles has expanded in recent years. Of particular interest is the use of these nanovehicles that deliver high concentrations of cytotoxic drugs to diseased tissues ...
    • Microbial Desalination Cell (MDC) in the Presence of Activated Carbon 

      Aidan, Ahmed; Husseini, Ghaleb; Yemendzhiev, H.; Nenov, Valentin; Rasheed, Ami; Chekkath, Hiba (American Scientific Publishers, 2014-10)
      This report studies the performance of a Microbial Desalination Cell (MDC) in the presence ofactivated carbon in both the cathode and anode chambers. The large surface area of the activatedcarbon provides surface for ...
    • Microbial Desalination Cells Technology: A Review and a Case Study 

      Saeed, Henna M; Husseini, Ghaleb; Yousef, Sharifeh; Saif, Jawaria; Al-Asheh, Sameer; Azzam, Sara; Khawaga, Rehab Ibrahim; Abu Fara, Abdullah; Aidan, Ahmad (Elsevier, 2015-03)
      The microbial desalination cell (MDC) is a newly-developed technology which integrates the microbial fuel cell (MFC) process and electrodialysis for wastewater treatment, water desalination and production of renewable ...
    • Modeling of Anti-cancer Drug Release Kinetics from Liposomes and Micelles: A review 

      AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (Institute of Electrical and Electronics Engineers, 2021)
      Nanocarriers, such as liposomes and micelles, were developed to enhance the delivery of therapeutic drugs to malignant tissues. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from ...
    • Modeling the Effects of Chemotherapy and Immunotherapy on Tumor Growth 

      El Haout, Sara; Fatani, Maymunah; Abu Farha, Nadia Khalil Mohammad; AlSawaftah, Nour Majdi; Mortula, Maruf; Husseini, Ghaleb (American Scientific Publishers, 2021)
      Mathematical modeling has been used to simulate the interaction of chemotherapy and immunotherapy drugs intervention with the dynamics of tumor cells growth. This work studies the interaction of cells in the immune system, ...
    • Over-Pressure Suppresses Ultrasonic-Induced Drug Uptake 

      Stringham, S. Briant; Viskovska, Maria A.; Richardson, Eric S.; Ohmine, Seiga; Husseini, Ghaleb; Murray, Byron K.; Pitt, William G. (Elseviser, 2008)
      Ultrasound (US) is used to enhance and target delivery of drugs and genes to cancer tissues. The present study further examines the role of acoustic cavitation in US-induced permeabilization of cell membranes and subsequent ...
    • Rapid Separation of Bacteria from Blood - Review and Outlook 

      Pitt, William G.; Alizadeh, Mahsa; Husseini, Ghaleb; McClellan, Daniel S.; Buchanan, Clara M.; Bledsoe, Colin G.; Blanco, Rae; Melville, Madison; Hunter, Alex K.; Robison, Richard A.; Roeder, Beverly L. (American Institute of Chemical Engineers (AIChE), 2016)
      The high morbidity and mortality rate of bloodstream infections involving antibiotic‐resistant bacteria necessitate a rapid identification of the infectious organism and its resistance profile. Traditional methods based ...
    • Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy 

      Al Bostami, Rouba D.; Abuwatfa, Waad Hussein; Husseini, Ghaleb (MDPI, 2022-08)
      Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient ...