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Factors Affecting the Acoustic In Vitro Release of Calcein from PEGylated Liposomes
(American Scientific Publishers, 2019)
Typical methods used in cancer treatment, including chemotherapy, are debilitating because of the various adverse side effects experienced by cancer patients. The free drug injected into the patient at given doses affects ...
Preliminary Results of Combining Low Frequency Low Intensity Ultrasound and Liposomal Drug Delivery to Treat Tumors in Rats
(American Scientific Publishers, 2011)
Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero- 3-phosphoethanolamine-N-[carboxy ...
Review on Triggered Liposomal Drug Delivery with a Focus on Ultrasound
(Bentham Science Publishers, 2015)
Chemotherapy is widely used for cancer treatment; however, it causes unwanted side effects in patients. To avoid these adverse effects, nanocarriers have been developed, which can be loaded with the chemotherapeutic agents, ...
Comparing microbubble cavitation at 500 kHz and 70 kHz related to micellar drug delivery using ultrasound
(Elsevier, 2013)
We have previously reported that ultrasonic drug release at 70 kHz was found to correlate with the presence of subharmonic emissions. No evidence of drug release or of the subharmonic emissions were detected in experiments ...
Predicting the Release of Chemotherapeutics From the Core of Polymeric Micelles Using Ultrasound
(IEEE Explore, 2015)
In this paper, the estimation of acoustic drug release from micelles is addressed. The release is measured as a decrease in fluorescence once ultrasound is applied. Initially, a Kalman filter is used to fuse the drug ...
Factors affecting acoustically triggered release of drugs from polymeric micelles
(Elsevier, 2000)
A custom ultrasonic exposure chamber with real-time fluorescence detection was used to measure acoustically-triggered drug release from Pluronic P-105 micelles under continuous wave (CW) or pulsed ultrasound in the frequency ...
Role of frequency and mechanical index in ultrasonic-enhanced chemotherapy in rats
(Springer, 2009)
Purpose The therapeutic effect of ultrasound and micellar-encapsulated doxorubicin was studied in vivo using a tumor-bearing rat model with emphasis on how tumor growth rate is affected by ultrasonic parameters such as ...
The use of ultrasound to release chemotherapeutic drugs from micelles and liposomes
(Taylor & Francis, 2014)
Several drug delivery systems have been investigated to reduce the side effects of chemotherapy by encapsulating the therapeutic agent in a nanosized carrier until it reaches the tumor site. Many of these particles are ...
Ultrasound-Mediated Drug Delivery in Cancer Therapy: A Review
(American Scientific Publishers, 2020)
The use of ultrasound as a medical diagnostic tool began in the 1940s. Ever since, the medical applications of ultrasound have included imaging, tumor ablation, and lithotripsy; however, an ever-increasing body of literature ...
Ultrasound-induced doxorubicin release from folate-targeted and non-targeted P105 micelles: a modeling study
(De Gruyter, 2016)
The aim of this work is to study the kinetics of ultrasound (70 kHz) – using a kinetic model that takes into account cavitation events and drug re-encapsulation upon the cessation of the acoustic field. The simulation ...