Browsing Department of Chemical and Biological Engineering by Author "ff88af8d-0958-4489-b6aa-c08cb30da85b"
Now showing items 1-14 of 14
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Effect of High-Frequency Ultrasound on Targeted Liposomes
AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (American Scientific Publishers, 2022)Delivering highly toxic drugs inside a safe carrier to tumors while achieving a controlled and effective drug release at the targeted sites represents an attractive approach to enhance drug efficiency while reducing its ... -
Effect of phospholipid head group on ultrasound‑triggered drug release and cellular uptake of immunoliposomes
Awad, Nahid S.; Paul, Vinod; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Nature, 2023)Liposomes are the most successful nanoparticles used to date to load and deliver chemotherapeutic agents to cancer cells. They are nano-sized vesicles made up of phospholipids, and targeting moieties can be added to their ... -
An Effective Anticancer Nano-approach for Melanoma and Breast Cancers Using Annona muricate Gold Nanoparticles
Imran, Muhammad; Husseini, Ghaleb; Awad, Nahid S.; Paul, Vinod; El-Haj, Babiker M.; Ali, Heyam Saad (Acta Scientific, 2021-09)Chemotherapy is preferred for the treatment and management of cancer; however, its efficacy is hindered by the off-target side effects of the currently used synthetic drugs. Thus, anticancer drugs with higher safety and ... -
Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review
Ibrahim, Mihad; Abuwatfa, Waad Hussein; Awad, Nahid S.; Sabouni, Rana; Husseini, Ghaleb (MDPI, 2022)Doxorubicin (DOX) is one of the most widely used anthracycline anticancer drugs due to its high efficacy and evident antitumoral activity on several cancer types. However, its effective utilization is hindered by the adverse ... -
In Vitro Evaluation of Ultrasound Effectiveness in Controlling Doxorubicin Release from Albumin-Conjugated Liposomes
Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Farooq, Afifa; Awad, Nahid S.; Husseini, Ghaleb (American Scientific Publishers, 2022)Functionalized liposomes are among the most promising antineoplastic agents delivery vehicles. Contemporaneous to their accretion at the tumor site, they need to be potentiated to release their cargo using a suitable ... -
Modeling of Drug Release Kinetics from Stimuli- Responsive Micelles and Liposomes: A review
AlSawaftah, Nour Majdi; Paul, Vinod; Awad, Nahid S.; Husseini, Ghaleb (IEEE, 2021)Nanocarriers such as micelles and liposomes were developed to enhance the delivery of therapeutic drugs to tumors. Internal or external stimuli can be applied to achieve spatiotemporal controlled release from these carriers. ... -
pH-Responsive Nanocarriers in Cancer Therapy
AlSawaftah, Nour Majdi; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)A number of promising nano-sized particles (nanoparticles) have been developed to conquer the limitations of conventional chemotherapy. One of the most promising methods is stimuli-responsive nanoparticles because they ... -
Photo-Induced Drug Release from Polymeric Micelles and Liposomes: Phototriggering Mechanisms in Drug-Delivery Systems
Salkho, Najla; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)Chemotherapeutic drugs are highly effective in treating cancer. However, the side effects associated with this treatment lower the quality of life of cancer patients. Smart nanocarriers are able to encapsulate these drugs ... -
Targeting Breast Cancer Using Hyaluronic Acid-Conjugated Liposomes Triggered with Ultrasound
Ben-Daya, Mohamed; Paul, Vinod; Awad, Nahid S.; AlSawaftah, Nour Majdi; Al-Sayah, Mohammad; Husseini, Ghaleb (American Science Publishers, 2021)The successful targeting of tumors can be achieved by conjugating targeting moieties to nanoparticles. These modifications allow nannocarriers to achieve greater targeting specificity through binding to specific receptors ... -
Thermosensitive Polymers and Thermo-Responsive Liposomal Drug Delivery Systems
Abuwatfa, Waad Hussein; Awad, Nahid S.; Pitt, William G.; Husseini, Ghaleb (MDPI, 2022)Temperature excursions within a biological milieu can be effectively used to induce drug release from thermosensitive drug-encapsulating nanoparticles. Oncological hyperthermia is of particular interest, as it is proven ... -
Transferrin‑modifed liposomes triggered with ultrasound to treat HeLa cells
AlSawaftah, Nour Majdi; Awad, Nahid S.; Paul, Vinod; Kawak, Paul S.; Al-Sayah, Mohammad; Husseini, Ghaleb (Nature, 2021)Targeted liposomes are designed to target specific receptors overexpressed on the surfaces of cancer cells. This technique ensures site-specific drug delivery to reduce undesirable side effects while enhancing the efficiency ... -
Tumor vasculature vs tumor cell targeting: Understanding the latest trends in using functional nanoparticles for cancer treatment
Awad, Nahid S.; Salkho, Najla; Abuwatfa, Waad Hussein; Paul, Vinod; AlSawaftah, Nour Majdi; Husseini, Ghaleb (Elsevier, 2023)Delivering drugs to tumors using nanoparticles (NPs) has shown promising potential in promoting targeted drug delivery of antineoplastic agents to enhance their efficiency while reducing the associated systemic toxicity. ... -
Ultrasound-sensitive cRGD-modified liposomes as a novel drug delivery system
AlSawaftah, Nour Majdi; Paul, Vinod; Kosaji, Doua Jamal; Khabbaz, Leen; Awad, Nahid S.; Husseini, Ghaleb (Taylor & Francis, 2022)Targeted liposomes enable the delivery of encapsulated chemotherapeutics to tumours by targeting specific receptors overexpressed on the surfaces of cancer cells; this helps in reducing the systemic side effects associated ... -
Ultrasound-Triggered Liposomes Encapsulating Quantum Dots as Safe Fluorescent Markers for Colorectal Cancer
Awad, Nahid S.; Haider, Mohamed; Paul, Vinod; AlSawaftah, Nour Majdi; Jagal, Jayalakshmi; Pasricha, Renu; Husseini, Ghaleb (MDPI, 2021)Quantum dots (QDs) are a promising tool to detect and monitor tumors. However, their small size allows them to accumulate in large quantities inside the healthy cells (in addition to the tumor cells), which increases their ...