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    Ultrasonically Controlled Albumin-conjugated Liposomes for Breast Cancer Therapy

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    ACNB Ultrasonically Controlled Albumin-Modified Liposomes for Breast Cancer Therapy 19 Dec 2018.pdf (1.170Mb)
    Date
    2019
    Author
    Awad, Nahid S.
    Paul, Vinod
    Al-Sayah, Mohammad
    Husseini, Ghaleb
    Advisor(s)
    Unknown advisor
    Type
    Peer-Reviewed
    Article
    Postprint
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    Abstract
    Targeted liposomes have high potentials in the specific and effective delivery of their loaded therapeutic agents to the tumor site. Once at the tumor site, it is important that these liposomes are triggered to release their load in a controlled and effective manner. In this study, pegylated (stealth) liposomes conjugated to human serum albumin (HSA) were investigated for the delivery of a model drug (calcein) to breast cancer cells. The fluorescent results showed that calcein uptake by the two breast cancer cell lines (MDA-MB-231 and MCF-7) was significantly higher with the HSA-PEG liposomes compared to the non-targeted control liposomes. Furthermore, the exposure to low-frequency ultrasound (LFUS) resulted in a statistically significant uptake of calcein compared to the uptake without ultrasound. The described drug delivery (DD) system, which involves combining the targeted liposomal formulation with ultrasonic triggering techniques, promises a safe, effective and site-specific breast cancer therapy.
    DSpace URI
    http://hdl.handle.net/11073/16588
    External URI
    https://doi.org/10.1080/21691401.2019.1573175
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    • Department of Biology, Chemistry and Environmental Sciences
    • Department of Chemical and Biological Engineering

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